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Transfus Sci. 1994 Sep;15(3):189-96.

The role of alloreactive cytotoxic and lymphokine-secreting T lymphocytes in the development of acute graft-versus-host disease.

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  • Scripps Research Institute, Department of Immunology, La Jolla, CA 92037, USA.

Abstract

The development of acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation is mediated by alloreactive donor T cells infused with the bone marrow inoculum. This review discusses the role and significance of host-specific cytotoxic and lymphokine-secreting donor T cells for the prediction and generation of acute GVHD.

PMID:
10155540
[PubMed - indexed for MEDLINE]
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