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Trends Biotechnol. 1999 Jan;17(1):25-9.

Single-administration vaccines: controlled-release technology to mimic repeated immunizations.

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  • 1Pharmaceutical R&D, Genentech, South San Francisco, CA 94080, USA. cleland@gene.com

Abstract

The most effective mechanism for the elimination of disease from society is the use of vaccinations, but these often require repeated administration. However, single-administration vaccine formulations provide the repeated administrations automatically. One approach is the development of injectable controlled-release microsphere formulations containing the vaccine antigen that is released as a pulse 1-6 months after injection. The time of the pulse is dependent upon the rate of polymer degradation, which is dictated by the polymer's composition and molecular weight. This controlled-release technology may provide complete protection against disease after a single administration.

PMID:
10098275
[PubMed - indexed for MEDLINE]
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