Send to:

Choose Destination
See comment in PubMed Commons below
Trends Biotechnol. 1999 Jan;17(1):25-9.

Single-administration vaccines: controlled-release technology to mimic repeated immunizations.

Author information

  • 1Pharmaceutical R&D, Genentech, South San Francisco, CA 94080, USA.


The most effective mechanism for the elimination of disease from society is the use of vaccinations, but these often require repeated administration. However, single-administration vaccine formulations provide the repeated administrations automatically. One approach is the development of injectable controlled-release microsphere formulations containing the vaccine antigen that is released as a pulse 1-6 months after injection. The time of the pulse is dependent upon the rate of polymer degradation, which is dictated by the polymer's composition and molecular weight. This controlled-release technology may provide complete protection against disease after a single administration.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk