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    J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):334-6.

    Human cyclophilin has a significantly higher affinity for HIV-1 recombinant p55 than p24.

    Bristow R, Byrne J, Squirell J, Trencher H, Carter T, Rodgers B, Saman E, Duncan J.

    Source

    Murex Biotech Ltd., Dartford, Kent, UK. Richard.Bristow@abbott.com

    Abstract

    The ability of cyclophilin to bind a panel of recombinant HIV-gag proteins was assessed using sensitive, quantitative, sandwich enzyme-linked immunosorbant assays (ELISAs). Significantly higher binding to cyclophilin was observed when recombinants contained at least 12 carboxy-terminal amino acids of p17 in addition to p24 sequences. These results indicate that the carboxy-terminus of p17 is important for optimal binding of cyclophilin to p24 and support the theory that cyclophilin acts on the uncleaved HIV-1 gag (p17-p24) precursor.

    PMID:
    10096576
    [PubMed - indexed for MEDLINE]

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