Display Settings:

Format

Send to:

Choose Destination
BMJ. 1999 Mar 27;318(7187):833-7.

Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study Group.

Author information

  • 1Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales 2751, Australia. talley@pnc.com.au

Abstract

OBJECTIVES:

To determine whether eradication of Helicobacter pylori relieves the symptoms of functional dyspepsia.

DESIGN:

Multicentre randomised double blind placebo controlled trial.

SUBJECTS:

278 patients infected with H pylori who had functional dyspepsia.

SETTING:

Predominantly secondary care centres in Australia, New Zealand, and Europe.

INTERVENTION:

Patients randomised to receive omeprazole 20 mg twice daily, amoxicillin 1000 mg twice daily, and clarithromycin 500 mg twice daily or placebo for 7 days. Patients were followed up for 12 months.

MAIN OUTCOME MEASURES:

Symptom status (assessed by diary cards) and presence of H pylori (assessed by gastric biopsies and 13C-urea breath testing using urea labelled with carbon-13).

RESULTS:

H pylori was eradicated in 113 patients (85%) in the treatment group and 6 patients (4%) in the placebo group. At 12 months follow up there was no significant difference between the proportion of patients treated successfully by intention to treat in the eradication arm (24%, 95% confidence interval 17% to 32%) and the proportion of patients treated successfully by intention to treat in the placebo group (22%, 15% to 30%). Changes in symptom scores and quality of life did not significantly differ between the treatment and placebo groups. When the groups were combined, there was a significant association between treatment success and chronic gastritis score at 12 months; 41/127 (32%) patients with no or mild gastritis were successfully treated compared with 21/123 (17%) patients with persistent gastritis (P=0. 008).

CONCLUSION:

No convincing evidence was found that eradication of H pylori relieves the symptoms of functional dyspepsia 12 months after treatment.

Comment in

PMID:
10092259
[PubMed - indexed for MEDLINE]
PMCID:
PMC27795
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk