Am J Hum Genet. 1999 Apr;64(4):1177-85.

A note on power approximations for the transmission/disequilibrium test.

Source

Institute for Medical Statistics, University of Bonn, 53105 Bonn, Germany. knapp@imsdd.meb.uni-bonn.de

Abstract

The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite precise. By this method, it is also shown that a previously published power approximation of the TDT is erroneous.

PMID:: 10090903; [PubMed - indexed for MEDLINE]
PMCID:: PMC1377842

Free PMC Article

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified. [Am J Hum Genet. 2000]
Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified.
Göring HH, Terwilliger JD. Am J Hum Genet. 2000 Apr; 66(4):1310-27. Epub 2000 Mar 23.
Testing linkage disequilibrium in sibships. [Am J Hum Genet. 2000]
Testing linkage disequilibrium in sibships.
Siegmund KD, Langholz B, Kraft P, Thomas DC. Am J Hum Genet. 2000 Jul; 67(1):244-8. Epub 2000 May 30.
Exploiting excess sharing: a more powerful test of linkage for affected sib pairs than the transmission/disequilibrium test. [Am J Hum Genet. 2000]
Exploiting excess sharing: a more powerful test of linkage for affected sib pairs than the transmission/disequilibrium test.
Wicks J. Am J Hum Genet. 2000 Jun; 66(6):2005-8. Epub 2000 Apr 28.
Review Combining the case-control methodology with the small size transmission/disequilibrium test for multiallelic markers. [Eur J Hum Genet. 2005]
Review Combining the case-control methodology with the small size transmission/disequilibrium test for multiallelic markers.
Guo W, Fung WK. Eur J Hum Genet. 2005 Sep; 13(9):1007-12.
Review Genotype-environment interaction in transmission disequilibrium tests. [Adv Genet. 2001]
Review Genotype-environment interaction in transmission disequilibrium tests.
Eaves LJ, Sullivan P. Adv Genet. 2001; 42:223-40.

See reviews... See all...

Cited by 31 PubMed Central articles

Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India. [BMC Med Genet. 2011]
Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India.
Mehrotra S, Fakiola M, Oommen J, Jamieson SE, Mishra A, Sudarshan M, Tiwary P, Rani DS, Thangaraj K, Rai M, et al. BMC Med Genet. 2011 Dec 15; 12:162. Epub 2011 Dec 15.
FLI1 polymorphism affects susceptibility to cutaneous leishmaniasis in Brazil. [Genes Immun. 2011]
FLI1 polymorphism affects susceptibility to cutaneous leishmaniasis in Brazil.
Castellucci L, Jamieson SE, Miller EN, de Almeida LF, Oliveira J, Magalhães A, Guimarães LH, Lessa M, Lago E, de Jesus AR, et al. Genes Immun. 2011 Oct; 12(7):589-94. Epub 2011 Jun 2.
No evidence for association between SLC11A1 and visceral leishmaniasis in India. [BMC Med Genet. 2011]
No evidence for association between SLC11A1 and visceral leishmaniasis in India.
Mehrotra S, Oommen J, Mishra A, Sudharshan M, Tiwary P, Jamieson SE, Fakiola M, Rani DS, Thangaraj K, Rai M, et al. BMC Med Genet. 2011 May 20; 12:71. Epub 2011 May 20.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A note on power approximations for the transmission/disequilibrium test.
A note on power approximations for the transmission/disequilibrium test.
Am J Hum Genet. 1999 Apr ;64(4):1177-85.

PubMed
Effect of a media-led education campaign on breast and cervical cancer screening...
Effect of a media-led education campaign on breast and cervical cancer screening among Vietnamese-American women.
Prev Med. 1999 Apr ;28(4):395-406.

PubMed
Role of urokinase plasminogen activator receptor in thrombospondin 1-mediated tu...
Role of urokinase plasminogen activator receptor in thrombospondin 1-mediated tumor cell invasion.
J Surg Res. 1999 Apr ;82(2):331-8.

PubMed
Phospholipase D1 in caveolae: regulation by protein kinase Calpha and caveolin-1...
Phospholipase D1 in caveolae: regulation by protein kinase Calpha and caveolin-1.
Biochemistry. 1999 Mar 23 ;38(12):3763-9.

PubMed
The boundaries of the silenced HMR domain in Saccharomyces cerevisiae.
The boundaries of the silenced HMR domain in Saccharomyces cerevisiae.
Genes Dev. 1999 Mar 15 ;13(6):698-708.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A note on power approximations for the transmission/disequilibrium test.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 31 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information