Antiproliferative effects of melatonin and CGP 52608

Biol Signals Recept. 1999 Jan-Apr;8(1-2):75-8. doi: 10.1159/000014572.

Abstract

The antiproliferative effects of melatonin and CGP 52608, an exogenous ligand for RZR/ROR receptors, are compared in the present paper. Both compounds exerted similar inhibitory effects on the proliferation of neoplastic cells in mouse colonic adenocarcinoma, DU 145 human prostate cancer, MCF-7 human breast carcinoma, and rat diethylstilbestrol-induced prolactinoma. Although it has been suggested that melatonin may influence the proliferation of tumor cells via RZR/ROR receptors, it cannot be excluded that the antiproliferative effects of melatonin and CGP 52608 are unrelated and mediated by different intracellular mechanisms.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Cell Division / drug effects*
  • Female
  • Humans
  • In Vitro Techniques
  • Ligands
  • Male
  • Melatonin / metabolism
  • Melatonin / pharmacology*
  • Mice
  • Neoplasms, Experimental / drug therapy
  • Neoplasms, Experimental / metabolism
  • Neoplasms, Experimental / pathology
  • Rats
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Thiazoles / metabolism
  • Thiazoles / pharmacology*
  • Thiosemicarbazones / metabolism
  • Thiosemicarbazones / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Thiazoles
  • Thiosemicarbazones
  • CGP 52608
  • Melatonin