Abstract
The antiproliferative effects of melatonin and CGP 52608, an exogenous ligand for RZR/ROR receptors, are compared in the present paper. Both compounds exerted similar inhibitory effects on the proliferation of neoplastic cells in mouse colonic adenocarcinoma, DU 145 human prostate cancer, MCF-7 human breast carcinoma, and rat diethylstilbestrol-induced prolactinoma. Although it has been suggested that melatonin may influence the proliferation of tumor cells via RZR/ROR receptors, it cannot be excluded that the antiproliferative effects of melatonin and CGP 52608 are unrelated and mediated by different intracellular mechanisms.
MeSH terms
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Animals
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Cell Division / drug effects*
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Female
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Humans
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In Vitro Techniques
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Ligands
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Male
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Melatonin / metabolism
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Melatonin / pharmacology*
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Mice
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Neoplasms, Experimental / drug therapy
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Neoplasms, Experimental / metabolism
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Neoplasms, Experimental / pathology
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Rats
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Receptors, Cytoplasmic and Nuclear / metabolism
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Thiazoles / metabolism
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Thiazoles / pharmacology*
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Thiosemicarbazones / metabolism
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Thiosemicarbazones / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Ligands
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Receptors, Cytoplasmic and Nuclear
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Thiazoles
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Thiosemicarbazones
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CGP 52608
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Melatonin