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Biochem Biophys Res Commun. 1999 Feb 5;255(1):129-32.

IL-1 rescues scleroderma myofibroblasts from serum-starvation-induced cell death.

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  • 1Rheumatology Division, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.


Normal senescent adult human fibroblasts are relatively insensitive to the effects of serum deprivation in culture. In contrast, the myofibroblast phenotype, which is predominant in scleroderma-affected skin and cultured fibroblasts from scleroderma-affected skin, shows signs of deterioration within 3 days of serum starvation. The addition of IL-1 (5 ng/ml) prevents this deterioration. We propose that IL-1 is a factor promoting myofibroblast longevity with consequent fibrosis in scleroderma skin.

Copyright 1999 Academic Press.

[PubMed - indexed for MEDLINE]
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