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1: Neurology. 1999 Mar 10;52(4):854-7.Click here to read Links
Comment in:
Neurology. 2000 Jan 25;54(2):537.

Creatine monohydrate increases strength in patients with neuromuscular disease.

Tarnopolsky M, Martin J.

Department of Neurology/Neurological Rehabilitation and Kinesiology, McMaster University Medical Center, Hamilton, Ontario, Canada. tarnopol@mcmaster.ca

Creatine monohydrate has been shown to increase strength in studies of young healthy subjects and in a few studies with patients. Creatine monohydrate (10 g daily for 5 days to 5 g daily for 5 days) was administered to patients with neuromuscular disease in a pilot study (Study 1; n = 81), followed by a single-blinded study (Study 2; n = 21). Body weight, handgrip, dorsiflexion, and knee extensor strength were measured before and after treatment. Creatine administration increased all measured indices in both studies. Short-term creatine monohydrate increased high-intensity strength significantly in patients with neuromuscular disease.

PMID: 10078740 [PubMed - indexed for MEDLINE]