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Neurology. 1999 Mar 10;52(4):782-5.

Neurologic side effects in neuroleptic-naive patients treated with haloperidol or risperidone.

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  • 1Department of Psychiatry and Behavioural Neurosciences, McMaster University Medical Centre, Hamilton, Ontario, Canada.

Abstract

OBJECTIVE:

To compare the side effect profile of risperidone with that of oral haloperidol in patients with no previous exposure to antipsychotic drugs (APDs).

BACKGROUND:

Early studies suggested that the APD risperidone may have a side effect profile comparable with that of placebo. These early studies involved patients with chronic schizophrenia and a long history of APD use. Very little information is available regarding the neurologic side effects of risperidone in patients without previous APD exposure.

METHODS:

The authors prospectively studied 350 consecutive neuroleptic-naive patients admitted to their acute-care psychiatry service; 34 of these were treated with risperidone (mean dose, 3.2 mg/d) and 212 were treated with low-dose haloperidol (mean dose 3.7 mg/d). All patients were assessed on admission and twice weekly thereafter using rating scales for dystonia, parkinsonism, akathisia, and dyskinesia.

RESULTS:

The incidence and severity of dystonic reactions, akathisia, parkinsonism, and dyskinesia were comparable in the risperidone- and haloperidol-treated groups.

CONCLUSIONS:

The neurologic side effect profile of low-dose risperidone is comparable with that of haloperidol in patients receiving APDs for the first time. Risperidone may not be a useful alternative to typical APDs for patients with PD and psychosis.

Comment in

PMID:
10078728
[PubMed - indexed for MEDLINE]
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