Abstract
Six-week-old male F344 rats were given a mixture of 0.01% diethylnitrosamine, 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine and 0.02% N-methyl-N'-nitro-N-nitrosoguanidine in their drinking water for 1 week. When 0.8%, 0.4%, or 0% of a mixture of non-steroidal anti-inflammatory drugs (NSAIDs) (acetaminophen, aspirin, dipyrone plus ethenzamide) was given after treatment with initiators in their food from weeks 2 to 68, the incidences of liver cell tumors in the rats were 68% (P < 0.001), 25% and 8%, respectively, but those of other tumors were not different. Administration of NSAIDs from weeks 2 to 104 without initiators showed no carcinogenicity. From the results of medium-term liver bioassay, it was suggested that dipyrone and ethenzamide had promoting effects and acetaminophen had an inhibitory effect on rat hepatocarcinogenesis.
MeSH terms
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Acetaminophen / administration & dosage
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Acetaminophen / adverse effects
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Administration, Oral
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Alanine Transaminase / blood
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Aspartate Aminotransferases / blood
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Aspirin / administration & dosage
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Aspirin / adverse effects
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Carcinogenicity Tests
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Dipyrone / administration & dosage
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Dipyrone / adverse effects
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Drug Combinations
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Liver Neoplasms, Experimental / chemically induced*
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Liver Neoplasms, Experimental / physiopathology
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Liver Neoplasms, Experimental / prevention & control
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Male
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Rats
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Rats, Inbred F344
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Salicylamides / administration & dosage
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Salicylamides / adverse effects
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Drug Combinations
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Salicylamides
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Acetaminophen
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Dipyrone
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Aspartate Aminotransferases
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Alanine Transaminase
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ethenzamide
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Aspirin