Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats

Cancer Lett. 1999 Jan 8;135(1):83-90. doi: 10.1016/s0304-3835(98)00273-0.

Abstract

Six-week-old male F344 rats were given a mixture of 0.01% diethylnitrosamine, 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine and 0.02% N-methyl-N'-nitro-N-nitrosoguanidine in their drinking water for 1 week. When 0.8%, 0.4%, or 0% of a mixture of non-steroidal anti-inflammatory drugs (NSAIDs) (acetaminophen, aspirin, dipyrone plus ethenzamide) was given after treatment with initiators in their food from weeks 2 to 68, the incidences of liver cell tumors in the rats were 68% (P < 0.001), 25% and 8%, respectively, but those of other tumors were not different. Administration of NSAIDs from weeks 2 to 104 without initiators showed no carcinogenicity. From the results of medium-term liver bioassay, it was suggested that dipyrone and ethenzamide had promoting effects and acetaminophen had an inhibitory effect on rat hepatocarcinogenesis.

MeSH terms

  • Acetaminophen / administration & dosage
  • Acetaminophen / adverse effects
  • Administration, Oral
  • Alanine Transaminase / blood
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Aspartate Aminotransferases / blood
  • Aspirin / administration & dosage
  • Aspirin / adverse effects
  • Carcinogenicity Tests
  • Dipyrone / administration & dosage
  • Dipyrone / adverse effects
  • Drug Combinations
  • Liver Neoplasms, Experimental / chemically induced*
  • Liver Neoplasms, Experimental / physiopathology
  • Liver Neoplasms, Experimental / prevention & control
  • Male
  • Rats
  • Rats, Inbred F344
  • Salicylamides / administration & dosage
  • Salicylamides / adverse effects

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Drug Combinations
  • Salicylamides
  • Acetaminophen
  • Dipyrone
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • ethenzamide
  • Aspirin