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J Clin Microbiol. 1999 Apr;37(4):1186-9.

Aspergillus meningitis: diagnosis by non-culture-based microbiological methods and management.

Author information

  • 1Departments of Medical Microbiology, University Hospital Nijmegen, Nijmegen, The Netherlands. p.verweij@mmb.azn.nl

Abstract

The performance of antibody detection, antigen detection, and Aspergillus genus-specific PCR for diagnosing Aspergillus meningitis was investigated with 26 cerebrospinal fluid (CSF) samples obtained from a single patient with proven infection caused by Aspergillus fumigatus. Immunoglobulin G antibodies directed against Aspergillus were not detected by enzyme-linked immunosorbent assay in CSF or serum. The antigen galactomannan was detected in the CSF 45 days before a culture became positive, and Aspergillus DNA was detected 4 days prior to culture. Decline of the galactomannan antigen titer in the CSF during treatment with intravenous and intraventricular amphotericin B and intravenous voriconazole corresponded with the clinical response to treatment.

PMID:
10074549
[PubMed - indexed for MEDLINE]
PMCID:
PMC88672
Free PMC Article

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