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J Gen Virol. 1999 Feb;80 ( Pt 2):477-83.

Immunological control of a murine gammaherpesvirus independent of CD8+ T cells.

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  • 1St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Abstract

Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.

PMID:
10073710
[PubMed - indexed for MEDLINE]
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