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1: Mech Dev. 1999 Feb;80(2):181-4.Click here to read Links

Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily.

Neuhaus H, Rosen V, Thies RS.

Genetics Institute Inc., 87 Cambridge Park Drive, Cambridge, MA 02140, USA.

Here we report the cloning and expression of murine BMP-10, a novel member of the TGF-beta superfamily. In the mouse embryo, BMP-10 expression begins at 9.0 d.p.c. and is restricted to the developing heart. Initially, BMP-10 expression localizes to the trabeculated part of the common ventricular chamber and to the bulbus cordis region. After 12.5 d.p.c., additional BMP-10 expression is seen in the atrial wall. The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart. Copyright 1998 Elsevier Science Ireland Ltd.

PMID: 10072785 [PubMed - indexed for MEDLINE]