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    Mech Dev. 1999 Feb;80(2):159-70.

    Regulation of chondrocyte differentiation by Cbfa1.

    Kim IS, Otto F, Zabel B, Mundlos S.

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    Universitäts-Kinderklinik Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany.

    Abstract

    Cbfa1, a developmentally expressed transcription factor of the runt family, was recently shown to be essential for osteoblast differentiation. We have investigated the role of Cbfa1 in endochondral bone formation using Cbfa1-deficient mice. Histology and in situ hybridization with probes for indian hedgehog (Ihh), collagen type X and osteopontin performed at E13.5, E14.5 and E17.5 demonstrated a lack of hypertrophic chondrocytes in the anlagen of the humerus and the phalanges and a delayed onset of hypertrophy in radius/ulna in Cbfa1-/- mice. Detailed analysis of Cbfa1 expression using whole mount in situ hybridization and a lacZ reporter gene reveled strong expression not only in osteoblasts but also in pre-hypertrophic and hypertrophic chondrocytes. Our studies identify Cbfa1 as a major positive regulator of chondrocyte differentiation.

    Copyright 1998 Elsevier Science Ireland Ltd.

    PMID:
    10072783
    [PubMed - indexed for MEDLINE]

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