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Curr Opin Genet Dev. 1999 Feb;9(1):40-8.

Histone acetylases and deacetylases in cell proliferation.

Author information

  • 1Wellcome/CRC Institute, Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, UK. tk106@mole.bio.cam.ac.uk

Abstract

There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals their involvement in cell-cycle regulation and differentiation. Furthermore, accumulating evidence suggests that deregulation of acetylase and deacetylase activity plays a causative role in the generation of cancer.

PMID:
10072350
[PubMed - indexed for MEDLINE]
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