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Trends Microbiol. 1999 Jan;7(1):29-36.

Escherichia coli mutator genes.

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  • 1Dept of Pharmacology and Molecular Toxicology, University of Massachusetts Medical School, Worcester 01655, USA.


The isolation and characterization of Escherichia coli mutator genes have led to a better understanding of DNA replication fidelity mechanisms and to the discovery of important DNA repair pathways and their relationship to spontaneous mutagenesis. Mutator strains in a population of cells can be beneficial in that they allow rapid selection of variants during periods of stress, such as drug exposure.

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