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Eur J Clin Nutr. 1999 Jan;53(1):1-7.

Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects.

Author information

  • 1TNO Nutrition and Food Research Institute, Zeist, The Netherlands.

Abstract

OBJECTIVE:

To study the effect of the intake of 15 g nondigestible oligosaccharides per day on various parameters of large-bowel function, as well as on blood lipid concentrations and glucose absorption in man.

DESIGN:

Latin square, randomized, double-blind, diet-controlled.

SETTING:

Metabolic research unit.

SUBJECTS:

Twelve apparently healthy men (mean age 23 years), recruited from the Institute's pool of volunteers, no drop-outs.

INTERVENTIONS:

Four treatment periods of 3 weeks: inulin, fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS) and control; analyses of stool weight, intestinal transit, faecal pH, short-chain fatty acids, bile acids, faecal enzymes, blood lipids and glucose absorption.

RESULTS:

As compared to the control treatment: higher concentration of faecal acetate (inulin and GOS, P < 0.05) and valerate (inulin, P < 0.05), significantly lower concentration of faecal deoxycholic acid (inulin and FOS, P < 0.05 and P< 0.02, respectively) and beta-glucuronidase activity (inulin and GOS, P < 0.05 and P < 0.02 respectively). Other changes of faecal parameters and those of blood lipids and glucose absorption were statistically not significant.

CONCLUSIONS:

RESULTS indicate that nondigestible oligosaccharides are (partly) fermented in the human colon, but in healthy young men the effects are limited. Also the consumption of 15 g nondigestible oligosaccharides does not seem to alter blood lipid concentrations and glucose absorption in our young healthy adults.

PMID:
10048793
[PubMed - indexed for MEDLINE]
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