Curr Opin Cell Biol. 1999 Feb;11(1):45-53.

Cytoplasmic dynein and dynactin in cell division and intracellular transport.

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University of Pennsylvania Department of Animal Biology 143 Rosenthal Building 3800 Spruce Street Philadelphia PA 19104-6046 USA. karkis@vet.upenn.edu

Abstract

Since the initial discovery of cytoplasmic dynein, it has become apparent that this microtubule-based motor is involved in several cellular functions including cell division and intracellular transport. Another multisubunit complex, dynactin, may be required for most, if not all, cytoplasmic dynein-driven activities and may provide clues to dynein's functional diversity. Recent genetic and biochemical findings have illuminated the cellular roles of dynein and dynactin and provided insight into the functional mechanism of this complex motor.

PMID:: 10047518; [PubMed - indexed for MEDLINE]

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Review The role of the dynactin complex in intracellular motility.
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Cited by over 100 PubMed Central articles

Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. [PLoS One. 2013]
Dynein and dynactin leverage their bivalent character to form a high-affinity interaction.
Siglin AE, Sun S, Moore JK, Tan S, Poenie M, Lear JD, Polenova T, Cooper JA, Williams JC. PLoS One. 2013; 8(4):e59453. Epub 2013 Apr 5.
Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2. [Int J Mol Sci. 2013]
Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2.
Pullikuth AK, Ozdemir A, Cardenas D, Bailey E, Sherman NE, Pfister KK, Catling AD. Int J Mol Sci. 2013 Feb 7; 14(2):3595-620. Epub 2013 Feb 7.
Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport. [J Neurosci. 2012]
Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport.
Mitchell DJ, Blasier KR, Jeffery ED, Ross MW, Pullikuth AK, Suo D, Park J, Smiley WR, Lo KW, Shabanowitz J, et al. J Neurosci. 2012 Oct 31; 32(44):15495-510.

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