J Pediatr Hematol Oncol. 1999 Jan-Feb;21(1):47-9.

Massive splenomegaly and Epstein-Barr virus-associated infectious mononucleosis in a patient with Gaucher disease.

Source

Department of Hematology/Oncology, University of Minnesota, Minneapolis, USA.

Abstract

PURPOSE:

Gaucher disease should be considered in the differential diagnosis of a patient with Epstein-Barr virus (EBV) infection who has unexplained or disproportionate splenomegaly.

PATIENTS AND METHODS:

A previously asymptomatic adolescent with EBV-associated infectious mononucleosis and massive splenomegaly is described. He was found to have Gaucher disease on bone marrow biopsy, which was performed to exclude a hematologic malignancy. The diagnosis was confirmed by assay of beta-glucosidase enzyme activity.

RESULTS:

Regression of splenomegaly and improving hematologic indices.

CONCLUSION:

Patients with infectious mononucleosis and disproportionate organomegaly should be investigated to exclude a hematologic malignancy or an underlying storage disorder such as Gaucher disease.

PMID:: 10029812; [PubMed - indexed for MEDLINE]

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