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Ned Tijdschr Geneeskd. 1998 Nov 14;142(46):2530-2.

[Sickle cell anemia during pregnancy].

[Article in Dutch]

Author information

  • 1Westeinde Ziekenhuis, afd. Verloskunde en Gynaecologie, Den Haag.


A 31-year-old pregnant Creole woman with sickle-cell anaemia went through a crisis of acute cholecystitis at 29 weeks' amenorrhoea. The crisis subsided after cholecystectomy, at which relative reduction of the number of sickle-cells by blood transfusions, adequate oxygenation, fluid, and antibiotic prophylaxis were provided. After 35 weeks' amenorrhoea, a healthy son was delivered by caesarean section. After the delivery, she developed fever and abdominal aches with a wound infection, and 10 days later a generalized epileptic attack. She recovered without sequelae. Pregnancy in a woman with sickle-cell anaemia may induce a sickle-cell crisis. The maternal morbidity and mortality and perinatal mortality are high, in spite of a pronounced decrease due to improved care.

[PubMed - indexed for MEDLINE]
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