Neurology. 1999 Feb;52(3):623-5.

HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy.

Clifford DB, Yiannoutsos C, Glicksman M, Simpson DM, Singer EJ, Piliero PJ, Marra CM, Francis GS, McArthur JC, Tyler KL, Tselis AC, Hyslop NE.

Source

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. cliffordd@neuro.wustl.edu

Abstract

Introduction of highly active antiretroviral therapy (HAART) has been associated with many changes in the complications of human immunodeficiency virus (HIV) infection. A cohort of 25 HIV patients with progressive multifocal leukoencephalopathy (PML) treated with HAART experienced a median survival of >46 weeks. This is an improvement in prognosis compared with recent historic experience and correlated with HIV RNA viral load reductions. We conclude that current HIV therapy is important in improving the outlook of PML in the setting of HIV.

Comment in

Neurology. 1999 Feb;52(3):440-1.

PMID:: 10025799; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Anti-HIV Agents

Grant Support

P05 R01 NS32228-04/NS/NINDS NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

HIV/AIDS Medicines - MedlinePlus Health Information

Supplemental Content

Related citations

Highly active antiretroviral therapy significantly improves the prognosis of patients with HIV-associated progressive multifocal leukoencephalopathy. [AIDS. 1998]
Highly active antiretroviral therapy significantly improves the prognosis of patients with HIV-associated progressive multifocal leukoencephalopathy.
Albrecht H, Hoffmann C, Degen O, Stoehr A, Plettenberg A, Mertenskötter T, Eggers C, Stellbrink HJ. AIDS. 1998 Jul 9; 12(10):1149-54.
Progressive multifocal leukencephalopathy in patients on highly active antiretroviral therapy: survival and risk factors of death. [J Acquir Immune Defic Syndr. 2004]
Progressive multifocal leukencephalopathy in patients on highly active antiretroviral therapy: survival and risk factors of death.
Wyen C, Hoffmann C, Schmeisser N, Wöhrmann A, Qurishi N, Rockstroh J, Esser S, Rieke A, Ross B, Lorenzen T, et al. J Acquir Immune Defic Syndr. 2004 Oct 1; 37(2):1263-8.
Cidofovir added to HAART improves virological and clinical outcome in AIDS-associated progressive multifocal leukoencephalopathy. [AIDS. 2000]
Cidofovir added to HAART improves virological and clinical outcome in AIDS-associated progressive multifocal leukoencephalopathy.
De Luca A, Giancola ML, Ammassari A, Grisetti S, Cingolani A, Paglia MG, Govoni A, Murri R, Testa L, Monforte AD, et al. AIDS. 2000 Sep 29; 14(14):F117-21.
Review The effect of highly active antiretroviral therapy-induced immune reconstitution on development and outcome of progressive multifocal leukoencephalopathy: study of 43 cases with review of the literature. [J Neurovirol. 2003]
Review The effect of highly active antiretroviral therapy-induced immune reconstitution on development and outcome of progressive multifocal leukoencephalopathy: study of 43 cases with review of the literature.
Cinque P, Bossolasco S, Brambilla AM, Boschini A, Mussini C, Pierotti C, Campi A, Casari S, Bertelli D, Mena M, et al. J Neurovirol. 2003; 9 Suppl 1:73-80.
Review Treatment options for AIDS patients with progressive multifocal leukoencephalopathy. [Expert Opin Pharmacother. 2009]
Review Treatment options for AIDS patients with progressive multifocal leukoencephalopathy.
Hernández B, Dronda F, Moreno S. Expert Opin Pharmacother. 2009 Feb; 10(3):403-16.

See reviews... See all...

Cited by 20 PubMed Central articles

From Clinical Presentation to the Outcome: the Natural History of PML in a Portuguese Population of HIV Infected Patients. [J Clin Med Res. 2011]
From Clinical Presentation to the Outcome: the Natural History of PML in a Portuguese Population of HIV Infected Patients.
Nery F, Franca M, Almeida I, Vasconcelos C. J Clin Med Res. 2011 Feb 12; 3(1):17-22.
Improved survival of HIV-1-infected patients with progressive multifocal leukoencephalopathy receiving early 5-drug combination antiretroviral therapy. [PLoS One. 2011]
Improved survival of HIV-1-infected patients with progressive multifocal leukoencephalopathy receiving early 5-drug combination antiretroviral therapy.
Gasnault J, Costagliola D, Hendel-Chavez H, Dulioust A, Pakianather S, Mazet AA, de Goer de Herve MG, Lancar R, Lascaux AS, Porte L, et al. PLoS One. 2011; 6(6):e20967. Epub 2011 Jun 30.
Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era. [Patholog Res Int. 2011]
Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era.
Cedeno-Laurent F, Penalva de Oliveira AC, Vidal JE, Trujillo JR. Patholog Res Int. 2011 Feb 22; 2011:562427. Epub 2011 Feb 22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

HAART improves prognosis in HIV-associated progressive multifocal leukoencephalo...
HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy.
Neurology. 1999 Feb ;52(3):623-5.

PubMed
Clear cell sarcoma (malignant melanoma) of soft parts: A clinicopathologic study...
Clear cell sarcoma (malignant melanoma) of soft parts: A clinicopathologic study of 30 cases.
Cancer. 1999 Sep 15 ;86(6):969-75.

PubMed
Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches i...
Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.
Cell. 2008 Sep 5 ;134(5):828-42.

PubMed
[In vitro activity of methylrosaniline chloride (gentian violet) as disinfectant...
[In vitro activity of methylrosaniline chloride (gentian violet) as disinfectant against Candida spp. and Trichosporon spp. isolated from blood samples].
Kansenshogaku Zasshi. 2006 Nov ;80(6):651-5.

PubMed
Isoprene emission from a subarctic peatland under enhanced UV-B radiation.
Isoprene emission from a subarctic peatland under enhanced UV-B radiation.
New Phytol. 2007 ;176(2):346-55.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: