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    Immunity. 1999 Jan;10(1):127-36.

    Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.

    Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M.

    Source

    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

    Abstract

    An interleukin-18 binding protein (IL-18BP) was purified from urine by chromatography on IL-18 beads, sequenced, cloned, and expressed in COS7 cells. IL-18BP abolished IL-18 induction of interferon-gamma (IFNgamma), IL-8, and activation of NF-kappaB in vitro. Administration of IL-18BP to mice abrogated circulating IFNgamma following LPS. Thus, IL-18BP functions as an inhibitor of the early Th1 cytokine response. IL-18BP is constitutively expressed in the spleen, belongs to the immunoglobulin superfamily, and has limited homology to the IL-1 type II receptor. Its gene was localized on human chromosome 11q13, and no exon coding for a transmembrane domain was found in an 8.3 kb genomic sequence. Several Poxviruses encode putative proteins highly homologous to IL-18BP, suggesting that viral products may attenuate IL-18 and interfere with the cytotoxic T cell response.

    PMID:
    10023777
    [PubMed - indexed for MEDLINE]

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