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    Immunity. 1999 Jan;10(1):117-25.

    BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells.

    Ishiai M, Kurosaki M, Pappu R, Okawa K, Ronko I, Fu C, Shibata M, Iwamatsu A, Chan AC, Kurosaki T.

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    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan.

    Abstract

    Signaling through the B cell receptor (BCR) is essential for B cell function and development. Despite the key role of Syk in BCR signaling, little is known about the mechanism by which Syk transmits downstream effectors. BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)gamma 2 and JNK. The BCR-induced PLC gamma 2 activation, but not the JNK activation, was restored by introduction of PLC gamma 2 membrane-associated form into BLNK-deficient B cells. As JNK activation requires both Rac1 and PLC gamma 2, our results suggest that BLNK regulates the Rac1-JNK pathway, in addition to modulating PLC gamma 2 localization.

    PMID:
    10023776
    [PubMed - indexed for MEDLINE]

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