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Immunity. 1999 Jan;10(1):93-103.

RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.

Author information

  • 1Department of Pediatrics, Stanford University School of Medicine, California 94305-5208, USA.

Abstract

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first "late" T lymphocyte associated transcription factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.

PMID:
10023774
[PubMed - indexed for MEDLINE]
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