Cancer-associated retinopathy in a patient with non-small-cell lung carcinoma

Lung Cancer. 1998 Nov;22(2):149-52. doi: 10.1016/s0169-5002(98)00062-2.

Abstract

Cancer-associated retinopathy (CAR) is a paraneoplastic syndrome most often associated with small-cell lung carcinoma (SCLC), and it has been reported in patients with other malignancies. Antibodies against recoverin, a 23-kDa protein, have been found in patients with CAR suggesting an autoimmune phenomenon. Herein is the first report of a patient with non-small-cell lung cancer (NSCLC) in whom anti-recoverin antibodies were detected in the serum. Steroid therapy, chemotherapy, and radiation therapy did not help the patient's vision. Progressive loss of vision in patients with lung cancer should, potentially, be tested for CAR.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Neoplasm / blood
  • Antigens, Neoplasm / immunology
  • Biomarkers, Tumor / blood
  • Calcium-Binding Proteins / immunology
  • Carcinoma, Non-Small-Cell Lung / blood
  • Carcinoma, Non-Small-Cell Lung / complications*
  • Eye Proteins*
  • Female
  • Hippocalcin
  • Humans
  • Lipoproteins*
  • Lung Neoplasms / blood
  • Lung Neoplasms / complications*
  • Nerve Tissue Proteins*
  • Paraneoplastic Syndromes / blood
  • Paraneoplastic Syndromes / etiology*
  • Recoverin
  • Retinal Diseases / blood
  • Retinal Diseases / etiology*

Substances

  • Antibodies, Neoplasm
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Calcium-Binding Proteins
  • Eye Proteins
  • Lipoproteins
  • Nerve Tissue Proteins
  • RCVRN protein, human
  • Recoverin
  • Hippocalcin