The pharmacology of galanthamine and its analogues

Pharmacol Ther. 1995;68(1):113-28. doi: 10.1016/0163-7258(95)02002-0.

Abstract

Galanthamine is an alkaloid found in the bulbs of snowdrops and several Amaryllidaceae plants. At submicromolar concentrations, it inhibits acetylcholinesterase activity, but it is much less potent against butyrylcholinesterase activity. Galanthamine has been used in anaesthetics to reverse neuromuscular paralysis by tubocurarine-like muscle relaxants, but it is a tertiary amine that gets into the brain to cause central effects. Galanthamine is being studied as a possible therapeutic agent in Alzheimer's disease because of its central cholinergic effects. Positive effects have been demonstrated in several learning and memory tests in animals.

Publication types

  • Review

MeSH terms

  • Animals
  • Central Nervous System / drug effects
  • Cholinesterase Inhibitors / pharmacology*
  • Galantamine / pharmacokinetics
  • Galantamine / pharmacology*
  • Humans
  • Nootropic Agents / pharmacology
  • Parasympathomimetics / pharmacology

Substances

  • Cholinesterase Inhibitors
  • Nootropic Agents
  • Parasympathomimetics
  • Galantamine