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    RecName: Full=ATP-sensitive inward rectifier potassium channel 12; AltName: Full=Inward rectifier K(+) channel Kir2.2; Short=IRK-2; AltName: Full=Inward rectifier K(+) channel Kir2.2v; AltName: Full=Potassium channel, inwardly rectifying subfamily J member 12

    UniProtKB/Swiss-Prot: Q14500.2

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        View conserved domains detected in this protein sequence using CD-search.
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        Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
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      Articles about the KCNJ12 gene

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      Identical proteins for Q14500.2

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      Pathways for the KCNJ12 gene

      • Cholinergic synapse
        Cholinergic synapseAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as learn ... [bsid217716]
      • Classical Kir channels
        Classical Kir channelsClassical Kir channels are inwardly rectifying K+ channels with strong inwardly rectifying currents that contribute to highly negative resting membrane potential, prolonged action potential plateau an ... [bsid366229]
      • Activation of G protein gated Potassium channels
        Activation of G protein gated Potassium channelsActivation of Kir 3 channels occurs after binding of G beta gamma subunits of GPCR. Activation of Kir3/GIRK leads to K+ efflux. The dissociation of GPCR into G alpha and G beta gamma subunits is activ ... [bsid366226]
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      Reference sequence information

      • RefSeq protein
        See the reference protein sequence for ATP-sensitive inward rectifier potassium channel 12 (NP_066292.2).

      More about the KCNJ12 gene

      Homologs of the KCNJ12 gene

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      • Conserved Domains (Concise)
        Concise (top-scoring) list of conserved domains present in the current proteins as determined by a Conserved Domain Database search using RPS-BLAST. For each region on a protein query sequence, this set includes: (a) a specific hit, if one is available, (b) the conserved domain superfamily, and (c) the best-scoring hit that is classified as a multi-domain model, if the alignment is near-complete with respect to that multidomain model footprint.
      • Conserved Domains (Full)
        Full list of Conserved domains present in the current proteins as determined by a Conserved Domain Database search using RPS-BLAST. This set includes all domain models that meet or exceed the RPS-BLAST threshold for statistical significance, as well as the conserved domain superfamilies to which they belong.
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        Gene records referencing the current protein sequence records. Sequences included in Gene records are added manually by NCBI.
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        Corresponding Reference Sequence (RefSeq) records for UniProt protein records in the current set.
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        PubMed articles associated with the current protein record through related Gene database records. These articles include Reference into Function, citations in related OMIM, and those associated with sequences in the Gene record.
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        Graphical summary of three dimensional structures that contain one or more protein molecules similar in sequence to your query protein. Alignment footprints indicate regions of similarity between the query protein and the structure-based protein, with an option to view the 3D structure and corresponding sequence alignment interactively in the free Cn3D tool.
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