RecName: Full=6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; - Protein

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Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor microenvironment biomarker in human cancers. [Aging (Albany NY). 2023]
Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor microenvironment biomarker in human cancers.
Da Q, Huang L, Huang C, Chen Z, Jiang Z, Huang F, Shen T, Sun L, Yan Z, Ye X, et al. Aging (Albany NY). 2023 May 30; 15(10):4533-4559. Epub 2023 May 30.
Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation. [World J Surg Oncol. 2023]
Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation.
Cheng X, Jia X, Wang C, Zhou S, Chen J, Chen L, Chen J. World J Surg Oncol. 2023 Mar 28; 21(1):112. Epub 2023 Mar 28.
PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse. [Front Immunol. 2022]
PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse.
Larionova I, Patysheva M, Iamshchikov P, Kazakova E, Kazakova A, Rakina M, Grigoryeva E, Tarasova A, Afanasiev S, Bezgodova N, et al. Front Immunol. 2022; 13:1080501. Epub 2023 Jan 17.

RefSeq protein isoforms
See 29 reference sequence protein isoforms for the PFKFB3 gene.

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Q16875 [Domain Mapping of Disease Mut...]
Q16875
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
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reagents [ExactAntigen/Labome]
reagents
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Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

RecName: Full=6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; Short=6PF-...
RecName: Full=6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; Short=6PF-2-K/Fru-2,6-P2ase 3; Short=PFK/FBPase 3; AltName: Full=6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; AltName: Full=Renal carcinoma antigen NY-REN-56; AltName: Full=iPFK-2; Includes: RecName: Full=6-phosphofructo-2-kinase; Includes: RecName: Full=Fructose-2,6-bisphosphatase
gi|3023733|sp|Q16875.1|F263_HUMAN

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