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    RecName: Full=E3 ubiquitin-protein ligase TRIM21; AltName: Full=52 kDa Ro protein; AltName: Full=52 kDa ribonucleoprotein autoantigen Ro/SS-A; AltName: Full=RING finger protein 81; AltName: Full=Ro(SS-A); AltName: Full=Sjoegren syndrome type A antigen; Short=S...

    UniProtKB/Swiss-Prot: P19474.1

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        Find regions of similarity between this sequence and other sequences using BLAST.
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        View conserved domains detected in this protein sequence using CD-search.
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        Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
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        Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

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      Identical proteins for P19474.1

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      Pathways for the TRIM21 gene

      • Systemic lupus erythematosus
        Systemic lupus erythematosusSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certa ... [bsid83122]
      • Antigen processing: Ubiquitination & Proteasome degradation
        Antigen processing: Ubiquitination & Proteasome degradationIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T c ... [bsid366162]
      • Class I MHC mediated antigen processing & presentation
        Class I MHC mediated antigen processing & presentationMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular ba ... [bsid366161]
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      Reference sequence information

      • RefSeq protein
        See the reference protein sequence for E3 ubiquitin-protein ligase TRIM21 (NP_003132.2).

      More about the TRIM21 gene

      Homologs of the TRIM21 gene

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      Related information

      • BLink
        BLAST Link. Pre-computed sequence similarity results (BLAST) including alignments for the current protein against the NCBI nr protein database. Organism specific, RefSeq and other database subsets are available as well as access to a pre-computed multiple alignment.
      • Related Sequences
        Protein sequences related by sequence similarity (BLAST) score to the current records.
      • Identical Proteins
        Proteins with identical sequences to the records in the current set.
      • BioSystems
        Pathways and other biosystems containing the current proteins.
      • CDD Search Results
        Graphical display of conserved domains identified in the protein using RPS-BLAST. The concise results (top-scoring hits) are shown by default, with an option to view the full results, if desired. Click on any domain footprint in the graphical display to see more details and to view the query protein sequence embedded in the domain model’s multiple sequence alignment.
      • Conserved Domains (Concise)
        Concise (top-scoring) list of conserved domains present in the current proteins as determined by a Conserved Domain Database search using RPS-BLAST. For each region on a protein query sequence, this set includes: (a) a specific hit, if one is available, (b) the conserved domain superfamily, and (c) the best-scoring hit that is classified as a multi-domain model, if the alignment is near-complete with respect to that multidomain model footprint.
      • Conserved Domains (Full)
        Full list of Conserved domains present in the current proteins as determined by a Conserved Domain Database search using RPS-BLAST. This set includes all domain models that meet or exceed the RPS-BLAST threshold for statistical significance, as well as the conserved domain superfamilies to which they belong.
      • Domain Relatives
        Conserved Domain Architecture Retrieval Tool (cDART) results for proteins in the current set. cDART identifies proteins that have similar kinds of conserved domains with similar organization.
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        Free full-text articles in PubMed central that cite protein records in the current set.
      • Gene
        Gene records referencing the current protein sequence records. Sequences included in Gene records are added manually by NCBI.
      • Gene Genotype
        Genotype reports for single nucleotide polymorphisms (SNPs) associated with the current records.
      • GeneView in dbSNP
        Geneview in dbSNP showing single nucleotide polymorphisms (SNPs) mapped to the genes associated with the current records.
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        Graphical Map Viewer display of the current proteins mapped to assembled genomes. Protein sequences are aligned through the corresponding mRNA sequence.
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        Online Mendelian Inheritance in Man (OMIM) records that refer to protein records in the current set.
      • Protein (RefSeq)
        Corresponding Reference Sequence (RefSeq) records for UniProt protein records in the current set.
      • PubMed
        PubMed articles that cite the protein records in the current set. These are articles that report the International Nucleotide Database Collaboration (DDBJ, EMBL, GenBank) records. These articles are also linked to Reference Sequences derived from the GenBank records.
      • PubMed (Weighted)
        PubMed articles associated with the current protein record through related Gene database records. These articles include Reference into Function, citations in related OMIM, and those associated with sequences in the Gene record.
      • Related Structures (List)
        List of three dimensional structure records that contain one or more protein molecules similar in sequence to the current protein(s). Each 3D structure and its corresponding sequence data can be viewed interactively in the free Cn3D tool.
      • Related Structures (Summary)
        Graphical summary of three dimensional structures that contain one or more protein molecules similar in sequence to your query protein. Alignment footprints indicate regions of similarity between the query protein and the structure-based protein, with an option to view the 3D structure and corresponding sequence alignment interactively in the free Cn3D tool.
      • Taxonomy
        NCBI Taxonomy entries and classification information for the source organisms of the current set of records.

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