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Status |
Public on Jan 22, 2014 |
Title |
Runx3 function in splenic NK cells activated in vivo by IL-15. |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent.
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Overall design |
To identify Runx3 regulated genes, NK cells were isolated from spleen of IL15/Ra injected WT and Runx3-/- mice and sorted to obtain 3 subpopulations of immature (CD27) and mature (DP and CD11c) NK cells.
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Contributor(s) |
Levanon D, Leshkowitz D, Groner Y |
Citation(s) |
24421391 |
Submission date |
Aug 22, 2013 |
Last update date |
Mar 04, 2019 |
Contact name |
Joseph Lotem |
E-mail(s) |
joseph.lotem@weizmann.ac.il
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Phone |
972-8-934-2342
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Organization name |
Weizmann institute of science
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Department |
Molecular genetics
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Street address |
P.O.B 26
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City |
Rehovot |
ZIP/Postal code |
76100 |
Country |
Israel |
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Platforms (1) |
GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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Samples (18)
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This SubSeries is part of SuperSeries: |
GSE52625 |
Runx3 Regulates Interleukin-15-Dependent Natural Killer Cell Activation |
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Relations |
BioProject |
PRJNA216118 |