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Series GSE1910 Query DataSets for GSE1910
Status Public on Dec 01, 2004
Title Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression.
Organism(s) Homo sapiens
Experiment type Expression profiling by array
Summary Since macrophage activation can now be studied at a global level using modern microarray and proteomic analyses, discovery of novel macrophage activation genes is inevitable and important for understanding HIV-associated dementia (HAD). We isolated two different types of primary human macrophages, microglia and monocyte-derived macrophages (MDM) from brain tissue and whole blood respectively. The microarray analysis of differentially regulated macrophage activation genes reported here supports our previous assertions that the mixed glia (MIX) cultured in starvation conditions (DMEM alone) are a non-activated, or “quiescent”, tissue culture model for studying macrophage activation in the brain. Transcript levels from these quiescent cultures provided a background level of gene expression, and allowed for the identification of upregulated macrophage activation genes in the MIX brain cultures upon treatment with an array of soluble activation factors: serum components, cytokines, and growth factors. We found that 914 genes in the MIX cultures and 734 genes in the MDM cultures had a greater than 2-fold increase in expression. We discovered 180 genes that were increased greater than 2 fold in both culture types. Microarray-specific statistical analyses were performed to complement fold change analysis: Significance Analysis of Microarrays (SAM), and Partek Pro. In the MIX cultures, we detected over a hundred fold increase in IL-1? and TIMP1 transcription; Caspase 9, S100A8 and 9, MMP-12, IL-8, MCP-1, MRC-1, and IL-6 were also upregulated. Activation of starved MDM cultures resulted in fewer upregulated genes compared to MIX cultures. Genes upregulated in both MIX and MDM included CCL2 (MCP1), CCL7, CXCL5, TNFSF14, kinases, and phosphatases. These microarray data may provide leads for identifying previously unknown neurotoxins, disease biomarkers, and pathways responsible for the neuronal apoptosis observed in HAD, and for the eventual identification of therapeutic targets and treatments.

For each gene, we performed a per-gene normalization, whereby an expression ratio was calculated by dividing the raw data from the activated media samples by the raw signal for the same gene from the non-activated media samples (Fig. 1). The same microarray data were also analyzed again using the very common per-chip normalization method recommended by the manufacturer where raw signals for each chip were multiplied by a scaling factor such that the trimmed mean for each chip became an arbitrary number (150) (Affymetrix, 2001).
The per-chip normalization method reduces person-to-person biological variability and potentially hides important changes in gene expression (Hill et al., 2001),(Bolstad et al., 2003). Therefore, we report our data using a per-gene normalization method, which yielded higher signal and low noise (uninteresting non-biological variability caused by chips, and/or experimental sample preparation), and given our experimental design, reduced person-to-person variability that these experiments cannot address directly. For later statistical analyses, the data were log transformed in order to obtain a normal distribution of the expression values of the >12,625 genes (Bolstad et al., 2003)
Keywords = Microarray
Keywords = macrophage
Keywords = microglia
Keywords = activation
Keywords = brain
Keywords: dose response
 
 
Contributor(s) Albright AV, Gonzalez-Scarano F
Citation(s)
Submission date Nov 01, 2004
Contact name Andrew V. Albright
E-mail(s) albrigh@mail.med.upenn.edu
Phone 215-898-3502
Organization name University of Pennsylvania
Department Neurology
Street address 255 CRB 415 Curie Blvd
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (14)
GSM34271 1Mix-serum
GSM34272 1Mix+serum
GSM34276 7Mix+serum

Table 2: Upregulated genes in macrophage cells header descriptions
aa_expt

Data table
aa_expt
name ()*S 8mdm+s 8mdm-s 14mdm+s 14mdm-s 17mdm+s 17mdm-s
cell type ()*S MDM MDM MDM MDM MDM MDM
serum ()*S + - + - + -
Expt number ()*S 8 8 14 14 17 17
Systematic avg fld change GSM34287 GSM34288 GSM34289 GSM34290 GSM34291 GSM34292 Common Synonyms Genbank Map Chromosome EC Description Product Phenotype Function Keywords PubMedID Custom Field 1 Custom Field 2 Custom Field 3 Type DBid GO biological process GO molecular function GO cellular component RefSeq UniGene SequenceSource_Affy SequenceDerivedFrom_Affy TranscriptID_Affy ProteinSimilaritiesBLASTP_Affy ProteinSimilaritiesBLASTx_Affy User Notes
38872_at 2367.534 0.617165 7.671008 2.9684 4.18E-04 2.124849 1.958477 ZNF230 ZNF230 U95044 19q13.32 19 zinc finger protein 230 zinc finger protein 230 GI:2232013 "regulation of transcription, DNA-dependent" DNA binding activity nucleus NM_006300 Hs.193583 6598826; ZNF230-like [Homo sapiens];0.0 ; 5454182; zinc finger protein 230; zinc finger protein [Homo sapiens];0.0
41757_at 1788.878 -2.360867 9.32E-04 54.049835 41.591274 3.955844 7.51433 VAPB VAPB W25933 0 "15b2 Human retina cDNA randomly primed sublibrary Homo sapiens cDNA, mRNA sequence." EST 4759302; VAMP (vesicle-associated membrane protein)-associated protein B and C; VAMP-associated protein C; VAMP-associated protein B; VAMP-associated 33 kDa protein [Homo sapiens];e-135 ; 7677066; VAMP-associated 33 kDa protein [Homo sapiens];e-131
535_s_at 211.962 -4.043579 0.007903 17.938824 9.936598 -3.92473 3.545036 NFKB2; LYT10; LYT-10 NFKB2 U20816 10q24 10 "Human nuclear factor kappa-B2 (NF-KB2) gene, partial cds." nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) binds to kappa chain gene of antibody in B cells GI:857455 "cell growth and/or maintenance; regulation of transcription, DNA-dependent; signal transduction" transcription co-activator activity; transcription factor activity nucleus NM_002502 "256299; p98=Rel/NF-kappa B p105 homolog [human, T lymphocytes, Peptide, 900 aa];0.0 ; 19923223; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); Nuclear factor of kappa light chain gene enhancer in B-cells 2 [Homo sapiens];0.0"
1435_f_at 92.543 11.72131 6.335199 -3.65075 0.018385 3.250642 0.85121 IFNA21 IFNA21 V00540 9p22 9 "interferon, alpha 21" "interferon, alpha 21" complementary DNA; interferon GI:32717; SWISS-PROT:P01568 defense response hematopoietin/interferon-class (D200-domain) cytokine receptor binding extracellular NM_002175 Hs.113211 "4504595; interferon, alpha 21 [Homo sapiens];e-103 ; 20178289; Interferon alpha-21 precursor (Interferon alpha-F) (LeIF F);e-103"
39524_at 88.171 27.296413 14.788162 7.212073 0.027466 0.396252 4.617662 RHO; RP4; OPN2 RHO U49742 3q21-q24 3 "the 5 exons of the human rhodopsin gene are similar to the 5 exons of the Bos taurus opsin gene; Human rhodopsin gene, complete cds." rhodopsin "Night blindness, congenital stationery, rhodopsin-related; Retinitis pigmentosa, autosomal recessive; Retinitis pigmentosa-4, autosomal dominant" opsin; rhodopsin GI:1236137 "rhodopsin mediated signaling; phototransduction, visible light; G-protein coupled receptor protein signaling pathway; vision" G-protein coupled photoreceptor activity integral to plasma membrane NM_000539 "3024288; Rhodopsin;0.0 ; 4506527; rhodopsin; rhodopsin (retinitis pigmentosa 4, autosomal dominant) [Homo sapiens];0.0"
37998_at 81.440 -13.885502 0.021017 49.616154 69.92783 19.63835 3.440105 SKIV2L SKIV2L U09877 6p21 6 superkiller viralicidic activity 2-like (S. cerevisiae) superkiller viralicidic activity 2-like homolog GI:1754827 regulation of translation ATP dependent RNA helicase activity; ATP binding; RNA binding NM_006929 Hs.89864 2347134; helicase [Homo sapiens];0.0 ; 20631987; superkiller viralicidic activity 2-like homolog; 170A; superkiller viralicidic activity 2 (S. cerevisiae homolog)-like; helicase SKI2W [Homo sapiens];0.0
31391_at 80.734 1201.681 0 482.0556 434.96854 749.4565 989.57086 HAP1 HAP1 AF040723 17q21.2-q21.3 17 huntingtin-associated protein 1 (neuroan 1) huntingtin-associated protein 1 isoform 1; huntingtin-associated protein 1 isoform 2 GI:3282691 pathogenesis; nonselective vesicle transport; synaptic transmission; development actin cytoskeleton NM_003949; NM_177977 Hs.158300
39636_at 74.645 0.215687 3.798587 9.7568 10.070873 1.885601 0.008459 AL079294 Xp22 23 Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 362780 FLI_CDNA Hs.29952
39031_at 71.975 -2.707169 -12.351533 4.007132 0.01873 12.84452 13.054976 COX7A1 COX7A1 AA152406 19q13.1 19 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) EST Hs.421621 4502987; cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) precursor; cytochrome c oxidase subunit VIIa heart/muscle isoform [Homo sapiens];5e-39 ; 8117738; cytochrome c oxidase polypeptide VIIa-heart precursor [Hylobates lar];5e-35
34749_at 55.785 14.689792 0.088752 202.91418 206.7908 85.538155 99.56117 SLC31A2 SLC31A2 U83461 9q31-q32 9 "solute carrier family 31 (copper transporters), member 2" "solute carrier family 31 (copper transporters), member 2" GI:2315989 copper ion transport copper ion transporter activity integral to plasma membrane NM_001860 Hs.24030 "4507017; solute carrier family 31 (copper transporters), member 2; hCTR2; copper transporter 2 [Homo sapiens];2e-77 ; 13384632; solute carrier family 31, member 2 [Mus musculus];1e-56"
31464_at 52.623 -2.776108 0.168131 -4.574492 0.03933 -3.202154 -3.384381 DCT DCT AJ000503 13q32 13 5.3.3.12 "dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)" "dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)" DOPAchrome tautomerase TRP-2; tyrosinase-related protein 2 GI:3319963; GOA:O75767; SPTREMBL:O75767 epidermal differentiation; melanin biosynthesis from tyrosine; metabolism dopachrome isomerase activity; copper ion binding; oxidoreductase activity integral to membrane NM_001922 Hs.301865 "6041667; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); Dopachrome tautomerase (dopachrome delta-isomerase; tyrosinase-related protein 2) [Homo sapiens];0.0 ; 6753614; dopachrome tautomerase; tyrosinase-related protein-2 [Mus musculus];0.0"
802_at 51.420 -3.765123 -2.431506 22.255564 15.996835 18.62271 0.122623 TAF12 TAF12 X84002 1p35.2 1 "TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa" "TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kD" TAFII20 gene; transcription factor; transcription factor TFIID GI:791055; GOA:Q16514; SWISS-PROT:Q16514 "transcription initiation; regulation of transcription, DNA-dependent" protein binding; general RNA polymerase II transcription factor activity; DNA binding transcription factor TFIID complex; nucleus NM_005644 Hs.421646 "5032153; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kD; transcription initiation factor TFIID 20/15 kDa subunits; TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD [Homo sapiens];4e-88 ; 18044302; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kDa [Mus musculus];9e-85"
36504_at 47.847 13.501311 14.059057 8.098174 0.05712 13.909748 17.232864 FARS1 FARS1 AF097441 6p25.1 6 phenylalanine-tRNA synthetase 1 (mitochondrial) phenylalanine-tRNA synthetase aminoacylation of Phe-tRNA GI:3983103 tRNA processing; transport; phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity; tRNA binding; ATP binding; transporter activity soluble fraction; mitochondrion NM_006567 Hs.57969 5729820; phenylalanine-tRNA synthetase [Homo sapiens];0.0 ; 22267456; RIKEN cDNA 2810431B21 [Mus musculus];0.0
35546_at 43.576 3.015815 0.023377 3.099244 2.053472 1.061885 5.022938 SMC1L1 W28428 Xp11.22-p11.21 23 SMC1 structural maintenance of chromosomes 1-like 1 (yeast) EST Hs.211602
31336_at 42.095 -0.254216 -4.547927 -0.381936 0.04023 -1.703518 -2.194804 VN1R1; V1RL1; ZVNH1; ZVNR1; VNR19I1 AC004076 19q13.4 19 "hypothetical ZNF-like protein; Homo sapiens chromosome 19, cosmid R30217, complete sequence." vomeronasal 1 receptor 1 HTG GI:2822143 NM_020633

Total number of rows: 752

Table truncated, full table size 385 Kbytes.




Table 1: Upregulated genes in mixed glial cells header descriptions
aa_expt

Data table
aa_expt
name ()*S 1mg+s 1mg-s 7mg+s 7mg-s 16mg+s 16mg-s 18mg+s 18mg-s
cell type ()*S MG MG MG MG MG MG MG MG
serum ()*S + - + - + - + -
Expt number ()*S 1 1 7 7 16 16 18 18
Systematic avg fld change GSM34272 GSM34271 GSM34276 GSM34277 GSM34278 GSM34279 GSM34280 GSM34281 Common Synonyms Genbank Map Chromosome EC Description Product Phenotype Function Keywords PubMedID GO biological process GO molecular function GO cellular component RefSeq UniGene SequenceSource_Affy SequenceDerivedFrom_Affy TranscriptID_Affy Title_Affy OverlappingTranscripts_Affy ProteinSimilaritiesBLASTP_Affy ProteinSimilaritiesBLASTx_Affy User Notes
1520_s_at 228.4532166 1859.3195 3.630263 65.46839 15.795599 570.34076 -20.852457 1410.6066 -9.771011 IL1B; IL-1; IL1F2; IL1-BETA IL1B X04500 2q14 2 Human gene for prointerleukin 1 beta. "interleukin 1, beta proprotein" interleukin 1 beta negative regulation of cell proliferation; apoptosis; immune response; signal transduction; regulation of cell cycle; cell-cell signaling; inflammatory response; antimicrobial humoral response (sensu Vertebrata) interleukin-1 receptor binding; signal transducer activity extracellular space NM_000576 "interleukin 1, beta" "Hs.126256; 4; NM_000576; interleukin 1, beta; chr2; 111508580-111515596; -" "124303; Interleukin-1 beta precursor (IL-1 beta) (Catabolin);e-155 ; 10835145; interleukin 1, beta [Homo sapiens];e-155"
1693_s_at 145.6196083 2086.3008 -39.92122 946.34436 95.87252 842.04095 16.808502 1770.1975 331.25226 TIMP1; EPA; EPO; HCI; CLGI TIMP1 D11139 Xp11.3-p11.23 23 "Homo sapiens TIMP gene for tissue inhibitor of metalloproteinases, partial cds." tissue inhibitor of metalloproteinase 1 precursor tissue inhibitor of metalloproteinases positive regulation of cell proliferation; proteolysis and peptidolysis; development metalloendopeptidase inhibitor activity; metallopeptidase activity extracellular matrix NM_003254 "tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)" "Hs.433425; 8; NM_003254; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); chrX; 45703469-45706852; +" 31189; EPA glycoprotein [Homo sapiens];e-121 ; 4507509; tissue inhibitor of metalloproteinase 1 precursor; Erythroid-potentiating activity (tissue inhibitor of metalloproteinases); erythroid potentiating activity [Homo sapiens];e-122
38052_at 78.22883104 13.43681 7.882556 1044.2317 -26.421484 9.147746 4.150786 1.259902 7.722614 F13A1 F13A1 M14539 6p25.3-p24.3 6 2.3.2.13 "coagulation factor XIII, A1 polypeptide" coagulation factor XIII A1 subunit precursor Factor XIIIA deficiency factor XIII; fibrin; fibrinoligase; glycoprotein; plasma transglutaminase blood coagulation; peptide cross-linking blood coagulation factor activity; acyltransferase activity; protein-glutamine gamma-glutamyltransferase activity; calcium ion binding extracellular NM_000129 Hs.80424 "coagulation factor XIII, A1 polypeptide" "Hs.80424; 4; NM_000129; coagulation factor XIII, A1 polypeptide; chr6; 6129316-6305901; -" "4503631; coagulation factor XIII A1 subunit precursor; Coagulation factor XIII, A polypeptide; TGase [Homo sapiens];0.0 ; 119720; Coagulation factor XIII A chain precursor (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain);0.0"
486_at 46.29403157 232.08948 -25.497698 36.11685 10.269012 139.72354 1.090451 243.58368 -4.654393 CASP9 CASP9 U60521 1p36.3-p36.1 1 "caspase 9, apoptosis-related cysteine protease" caspase 9 isoform alpha preproprotein; caspase 9 isoform beta preproprotein cysteine protease which is activated by CPP32 and granzyme B caspase activation via cytochrome c; apoptotic program; proteolysis and peptidolysis enzyme activator activity; apoptosis regulator activity; caspase activity intracellular NM_001229; NM_032996 Hs.329502 "caspase 9, apoptosis-related cysteine protease" 14790128; caspase 9 isoform beta preproprotein; ICE-like apoptotic protease 6; apoptotic protease MCH-6; apoptotic protease activating factor 3 [Homo sapiens];e-151 ; 14790124; caspase 9 isoform alpha preproprotein; ICE-like apoptotic protease 6; apoptotic protease MCH-6; apoptotic protease activating factor 3 [Homo sapiens];0.0 ; 7513083; ICE-LAP6 - human;0.0 ; 4240552; caspase-9S precursor [Homo sapiens];e-151
37319_at 45.6921361 3.14268 -2.027489 1599.8124 8.963687 4.800601 3.08653 11.045011 -4.885505 IGFBP3; IBP3 IGFBP3 M35878 7p13-p12 7 "The AAs encoded by bases 5728-5736 and 5917-5926 may be ASN-linked glycosylation sites; insulin-like precursor; Homo sapiens growth factor-binding protein-3 precursor (IGFBP3) gene, complete cds." insulin-like growth factor binding protein 3 insulin-like growth factor binding protein 3 signal transduction; regulation of cell growth insulin-like growth factor binding extracellular space NM_000598 insulin-like growth factor binding protein 3 Hs.77326; 20; NM_000598; insulin-like growth factor binding protein 3; chr7; 45598146-45607015; - 4504617; insulin-like growth factor binding protein 3 [Homo sapiens];e-174 ; 6672069; insulin-like growth factor-binding protein 3 [Sus scrofa];e-147
1501_at 42.18979327 11.968056 -5.189592 225.4223 1.37147 -10.821526 -11.545265 -8.005999 -7.902514 IGF1 IGF1 X57025 12q22-q23 12 insulin-like growth factor 1 (somatomedin C) insulin-like growth factor 1 (somatomedin C) Growth retardation with deafness and mental retardation insulin-like growth factor I glycolate metabolism; positive regulation of cell proliferation; DNA replication; RAS protein signal transduction; muscle development; skeletal development; cell motility insulin-like growth factor receptor binding; peptide hormone NM_000618 Hs.308053 insulin-like growth factor 1 (somatomedin C) Hs.85112; 2; NM_000618; insulin-like growth factor 1 (somatomedin C); chr12; 102748437-102833086; - 11024682; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1 (somatomedia C) [Homo sapiens];4e-87
38650_at 37.632265 -23.351137 -31.40694 737.6403 -19.985542 -23.031183 -24.994549 -15.603114 -11.193801 IGFBP5 L27560 2q33-q36 2 insulin-like growth factor binding protein 5 insulin-like growth factor binding protein 5 insulin-like growth factor binding protein 5 NM_000599 Hs.380833 "Unknown (protein for IMAGE:4183312) [Homo sapiens], mRNA sequence"
38037_at 35.51586176 270.79684 -57.57165 65.418945 2.084805 40.44152 -9.724448 262.5361 -0.824814 DTR DTR M60278 5q23 5 diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) "Diphtheria, susceptibility to" heparin-binding EGF-like growth factor "positive regulation of cell proliferation; pathogenesis; muscle development; regulation of transcription, DNA-dependent; invasive growth; signal transduction" epidermal growth factor receptor binding; heparin binding; growth factor activity; DNA binding; receptor activity integral to plasma membrane; extracellular space; nucleus NM_001945 Hs.799 diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) Hs.799; 1; BC033097; diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); chr5; 140295460-140309208; - 1346256; Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF) (Diphteria toxin receptor) (DT-R);e-113 ; 4503413; diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); Diphtheria toxin receptor (heparin-binding EGF-like growth factor) [Homo sapiens];e-118 Q14487; HEPARIN-BINDING EPIDERMAL GROWTH FACTOR (FRAGMENT). length=51;5e-22; HBGF_MOUSE; Gene:DTR Gene:HEGFL HEPARIN-BINDING EGF-LIKE GROWTH FACTOR PRECURSOR (HB-EGF) (HBEGF). length=208;2e-83; HBGF_HUMAN; Gene:DTR Gene:HEGFL Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF) (Diphteria toxin receptor) (DT-R). length=208;1e-105; Q14486; HEPARIN-BINDING EPIDERMAL GROWTH FACTOR (FRAGMENT). length=58;1e-26; HBGF_RAT; Gene:DTR Gene:HEGFL HEPARIN-BINDING EGF-LIKE GROWTH FACTOR PRECURSOR (HB-EGF) (HBEGF). length=208;2e-85
41471_at 33.08823847 74.895706 -13.124682 296.26404 29.776459 155.44786 4.501713 180.5744 2.032655 S100A9 S100A9 W72424 1q21 1 S100 calcium binding protein A9 (calgranulin B) EST Hs.112405 S100 calcium binding protein A9 (calgranulin B) Hs.112405; 1; AF086362; S100 calcium binding protein A9 (calgranulin B); chr1; 149113418-149116177; + "4506773; S100 calcium-binding protein A9; calgranulin B [Homo sapiens];2e-63 ; 20150229; Chain A, Crystal Structure Of The Mrp14 Complexed With Chaps;9e-63"
40661_at 30.48158999 170.1238 1.461158 -0.469187 -2.989764 -1.26389 14.510572 17.348082 23.79271 NR4A3 NR4A3 D78579 9q22 9 "nuclear receptor subfamily 4, group A, member 3" "nuclear receptor subfamily 4, group A, member 3 isoform a; nuclear receptor subfamily 4, group A, member 3 isoform c; nuclear receptor subfamily 4, group A, member 3 isoform b" "Chondrosarcoma, extraskeletal myxoid" "cell growth and/or maintenance; regulation of transcription, DNA-dependent" thyroid hormone receptor activity; steroid hormone receptor activity; binding; transcription factor activity nucleus NM_006981; NM_173198; NM_173199; NM_173200 Hs.279522 "nuclear receptor subfamily 4, group A, member 3" "Hs.80561; 2; NM_006981; nuclear receptor subfamily 4, group A, member 3; chr9; 94327666-94370863; +"
35410_at 30.33151039 -10.387324 -13.570078 594.95807 -7.136735 1.05005 4.652772 -5.514465 -5.978237 CXCL6 CXCL6 U81234 4q21 4 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) chemotaxis; signal transduction; cell-cell signaling; inflammatory response chemokine activity NM_002993 Hs.164021 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) Hs.164021; 1; BC013744; chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); chr4; 74942068-74944038; + "4506849; chemokine (C-X-C motif) ligand 5; Small inducible cytokine subfamily B (Cys-X-Cys), member 5; small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78) [Homo sapiens];1e-45 ; 4506851; chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); Small inducible cytokine subfamily B (Cys-X-Cys), member b; small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2) [Homo sapiens];3e-59"
35668_at 29.27973325 417.26724 -18.87378 -14.392105 -7.898944 6.339575 -18.544285 156.98785 -0.594099 RAMP1 RAMP1 AJ001014 2q36-q37.1 2 receptor (calcitonin) activity modifying protein 1 receptor (calcitonin) activity modifying protein 1 precursor CRLR receptor-activity-modifying-protein RAMP1 gene regulation of G-protein coupled receptor protein signaling pathway; transport protein transporter activity; receptor activity integral to plasma membrane NM_005855 Hs.32989 receptor (calcitonin) activity modifying protein 1 Hs.32989; 3; NM_005855; receptor (calcitonin) activity modifying protein 1; chr2; 237449732-237502192; + 5032019; receptor (calcitonin) activity modifying protein 1 precursor; calcitonin receptor-like receptor activity modifying protein 1 [Homo sapiens];8e-86 ; 13928890; receptor-activity modifying protein 1 [Rattus norvegicus];2e-61
1396_at 24.79797003 -5.114514 -8.291613 475.66306 -7.142945 -12.916354 -13.918574 -8.225024 2.428165 IGFBP5 L27560 2q33-q36 2 insulin-like growth factor binding protein 5 insulin-like growth factor binding protein 5 insulin-like growth factor binding protein 5 NM_000599 Hs.380833 "Unknown (protein for IMAGE:4183312) [Homo sapiens], mRNA sequence" "Hs.380833; 2; BC008099; Unknown (protein for IMAGE:4183312) [Homo sapiens], mRNA sequence; chr2; 216258405-216259361; -"
31719_at 22.33061818 25.7081 41.078896 539.4339 6.037022 20.16329 -1.781424 57.040775 49.740013 FN1 FN1 X02761 2q34 2 fibronectin 1 fibronectin 1 isoform 1 preproprotein; fibronectin 1 isoform 2 preproprotein alternate splicing; fibronectin cell adhesion; cell motility; signal transduction cell adhesion molecule activity extracellular matrix; soluble fraction; extracellular space NM_002026; NM_054034 Hs.418138 fibronectin 1 Hs.287820; 9; NM_002026; fibronectin 1; chr2; 214949869-215025076; - 16933544; fibronectin 1 isoform 2 preproprotein; cold-insoluble globulin [Homo sapiens];0.0 ; 16933542; fibronectin 1 isoform 1 preproprotein; cold-insoluble globulin [Homo sapiens];0.0 ; 2506872; Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG);0.0 ; 12053817; migration stimulation factor FN70 [Homo sapiens];0.0
189_s_at 22.14727924 412.3433 -61.00955 -30.248852 24.80503 329.81033 101.43633 371.7957 99.37394 PLAUR; CD87; UPAR; URKR U09937 19q13 19 "Homo sapiens urokinase-type plasminogen receptor, exon 7." "plasminogen activator, urokinase receptor" chemotaxis; blood coagulation; cell surface receptor linked signal transduction U-plasminogen activator receptor activity plasma membrane; extrinsic to membrane NM_002659

Total number of rows: 919

Table truncated, full table size 603 Kbytes.




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