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Study Description

We have performed whole genome sequencing of 4 cases of pediatric acute megakaryoblastic leukemia to identify somatic genetic alterations driving leukemogenesis.

  • Study Types: Case Set, Cohort, Tumor vs. Matched-Normal
  • Number of study subjects that have individual level data available through Authorized Access: 4

Authorized Access
Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes, manifests, documents, data dictionaries, variable summaries, and truncated analyses.

Study Inclusion/Exclusion Criteria

Cases of acute megakaryoblastic leukemia as determined by morphology and flow cytometry of diagnostic bone marrow and/or peripheral blood samples.

Molecular Data
TypeVendorPlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Sequencing ILLUMINA HiSeq 2000 N/A N/A
Study History

Transcriptome, whole genome, and exome sequencing of acute megakaryoblastic leukemia and corresponding matched germline.

Selected publications
Diseases Related to Study (MESH terms)
Authorized Data Access Requests
Study Attribution
  • Principal Investigator
    • James R. Downing, MD. Dept. of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA
  • Institute
    • St. Jude Children's Research Hospital, Memphis, TN, USA