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Study Description

We have performed whole genome sequencing of 4 cases of pediatric acute megakaryoblastic leukemia to identify somatic genetic alterations driving leukemogenesis.

  • Study Types: Case Set, Cohort, Tumor vs. Matched-Normal
  • Number of study subjects that have individual level data available through Authorized Access: 4

Authorized Access
Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. If available, the site also contains data dictionaries, variable summaries, documents, and truncated analyses.

Study Inclusion/Exclusion Criteria

Cases of acute megakaryoblastic leukemia as determined by morphology and flow cytometry of diagnostic bone marrow and/or peripheral blood samples.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Sequencing Illumina HiSeq 2000 N/A N/A
Study History

Transcriptome, whole genome, and exome sequencing of acute megakaryoblastic leukemia and corresponding matched germline.

Selected publications
Diseases Related to Study (MESH terms)
Authorized Data Access Requests
Study Attribution
  • Principal Investigator
    • James R. Downing, MD. Dept. of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA
  • Institute
    • St. Jude Children's Research Hospital, Memphis, TN, USA