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Study Description

A genome-wide association study on smoking behavior and nicotine dependence in Icelandic smokers, assessed by the number of cigarettes smoked per day, smoking initiation and degree of dependence on nicotine.

The number of cigarettes smoked per day was ascertained through questionnaires given to individuals participating in multiple disease projects at deCODE Genetics (n=16,483). Smoking initiation was analyzed by comparing those that have ever smoked (n=16,483) versus those that have never smoked (n=21,667). The nicotine dependence analysis included 3,435 nicotine dependent cases (score 4 or higher on Fagerstrom Test for Nicotine Dependence (FTND) or endorsement of at least three of the seven Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV) criteria) and 3,344 low-quantity smokers as controls.

  • Study Types: Case Set, Case-Control
  • Number of study subjects that have individual level data available through Authorized Access:

Authorized Access
Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. If available, the site also contains data dictionaries, variable summaries, documents, and truncated analyses.

Study Inclusion/Exclusion Criteria

Individuals showing low genotype yield were excluded from the analysis (<98% call rate).

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Illumina HumanCNV370v1 370404 1047132
Selected publications
Diseases/Traits Related to Study (MESH terms)
Links to Other NCBI Resources
Authorized Data Access Requests
Study Attribution
  • Principal Investigator
    • Kari Stefansson, MD, PhD. deCODE Genetics, Inc., Reykjavik, Iceland
  • Co-Investigators
    • Thorgeir E. Thorgeirsson, PhD. deCODE Genetics, Inc., Reykjavik, Iceland
    • Jeffrey R. Gulcher, MD, PhD. deCODE Genetics, Inc., Reykjavik, Iceland
  • Funding Source
    • R01-DA017932. National Institutes of Health, Bethesda, MD, USA
    • deCODE Genetics. deCODE Genetics, Inc., Reykjavik, Iceland