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Study Description

The PUWMa GWAS of ADHD is a multi-site collaboration initiated to conduct a family-based association study from existing research samples. The source sample of ADHD families was ascertained at Massachusetts General Hospital (MGH, N=309 trios), Washington University at St. Louis (WASH-U, N=272 trios), and University of California at Los Angeles (UCLA, N=156 trios). All offspring met criteria for DSM-IV-TR attention-deficit hyperactivity disorder with childhood onset.

  • Study Type: Parent-Offspring Trios
  • Number of study subjects that have individual level data available through Authorized Access: 1383

Authorized Access
Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. If available, the site also contains data dictionaries, variable summaries, documents, and truncated analyses.

Study Inclusion/Exclusion Criteria

At MGH, initial affection status was based on DSM-IIIR criteria but lifetime DSM-IV-TR criteria was confirmed with Schedule for Affective Disorders and Schizophrenia for School-Age Children Epidemiologic Version (K-SADSE) at follow-up assessments. At UCLA, children and adolescents were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL). At WASH-U subjects were assessed with the Missouri Assessment of Genetics Interview for Children (MAGIC), a semi-structured psychiatric interview allowing DSM-III, DSM-IV, and ICD-10 diagnoses. Cases were excluded if they were positive for any of the following: neurological disorder, head injury resulting in concussion, lifetime diagnoses of schizophrenia or autism. With regard to cognitive ability, MGH and UCLA subjects with estimated Full Scale IQ was <80 or <70, respectively were excluded while subjects at WASH-U were excluded if parents reported mental retardation.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Illumina_Human_1M ILLUMINA_Human_1M 1069796 52075
Selected publications
Diseases Related to Study (MESH terms)
Links to Other NCBI Resources
Authorized Data Access Requests
Study Attribution
  • Co-Principal Investigators
    • Stephen V. Faraone, PhD. Departments of Psychiatry and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA
    • Eric Mick, ScD. Departments of Psychiatry at Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    • Susan Smalley, PhD. UCLA Department of Psychiatry and Biobehavioral Science, Los Angeles, CA, USA
    • Alexandre Todorov, PhD. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
  • Co-Investigators
    • Joseph Biederman, MD. Departments of Psychiatry at Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    • Alysa Doyle, PhD. Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    • Timothy Wilens, MD. Departments of Psychiatry at Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    • Janet Wozniak, MD. Departments of Psychiatry at Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    • Benjamin M. Neale, PhD. Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    • Sandra Loo, PhD. UCLA Department of Psychiatry and Biobehavioral Science, Los Angeles, CA, USA
    • James McCracken, MD. UCLA Department of Psychiatry and Biobehavioral Science, Los Angeles, CA, USA
    • James McGough, MD. UCLA Department of Psychiatry and Biobehavioral Science, Los Angeles, CA, USA
    • Stanley F. Nelson, MD. UCLA Department of Human Genetics, Los Angeles, CA, USA
    • Angela M. Reiersen, MD. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
  • Funding Source for Genotyping
    • Pfizer, Inc., New York, NY, USA
  • Funding Source for Sample Acquisition
    • U01MH085518. National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    • R13MH059126. National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    • R01MH62873. National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    • R01MH081803. National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    • R01NS054124. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    • K23MH001966. National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    • K24DA016264. National Institute of Drug Abuse, National Institutes of Health, Bethesda, MD, USA
    • R01MH058277. National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    • R01MH066237. National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA