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- Study Description
This substudy phs000282 Framingham CARe contains 50K genotypes from ~2,100 candidate genes across a range of cardiovascular, metabolic, and inflammatory syndromes, produced as part of NHLBI's Candidate Gene Association Resource (CARe) project. Summary level phenotypes for the Framingham Cohort study participants can be viewed at the top-level study page phs000007 Framingham Cohort. Individual level phenotype data and molecular data for all Framingham top-level study and substudies are available by requesting Authorized Access to the Framingham Cohort study phs000007.
NHLBI Candidate-gene Association Resource. The NHLBI initiated the Candidate gene Association Resource (CARe) to create a shared genotype/phenotype resource for analyses of the association of genotypes with phenotypes relevant to the mission of the NHLBI. The resource comprises nine cohort studies funded by the NHLBI including: Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Cleveland Family Study (CFS), Coronary Artery Risk Development in Young Adults (CARDIA), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Multi-Ethnic Study of Atherosclerosis (MESA), and the Sleep Heart Health Study (SHHS). A database of genotype and phenotype data was created that includes records for approximately 41,000 study participants with approximately 50,000 SNPs from more than 2,000 selected candidate genes. In addition, a genome wide association study using a 1,000K SNP Chip was conducted on approximately 8,900 African American participants drawn from five CARe cohorts: ARIC, CARDIA, CFS, JHS, and MESA. Data from individual cohorts is available to approved investigators through dbGaP.
- Study Weblink: The Framingham Heart Study
- Study Type: Longitudinal
Number of study subjects that have individual level data available through Authorized Access: 0
- Authorized Access
- Publicly Available Data (Public ftp)
- Study Inclusion/Exclusion Criteria
- Molecular Data
Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Targeted Region Genotyping Illumina CVDSNP55v1_A 49094 1050734
- Study History
Research milestones of the Framingham Heart Study can be found at http://www.framinghamheartstudy.org/about/milestones.html.
The Generation 1 (or Original) cohort Exam 1 took place between 1948 and 1953. Biennial exams have continued to the present. Exam 29 took place between 2006 and 2007. Exam 30 began in 2008.
The Generation 2 (or Offspring) cohort Exam 1 took place between 1971 and 1975. This cohort on average has been examined every three to four years. However, there was an eight year gap between Exam 1 and Exam 2 and a seven year gap between Exam 7 and Exam 8. Exam 8 took place between 2005 and 2008.
The Generation 3 cohort Exam 1 took place between 2002 and 2005. Exam 2 began in 2008.
The New Offspring Spouse cohort Exam 1 took place between 2003 and 2005. Exam 2 began in 2008.
- Selected publications
- Diseases Related to Study (MESH terms)
- Authorized Data Access Requests
- Study Attribution