Name: rs74505897
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs74505897

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr15:88858148 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: C>T
Variation Type: SNV Single Nucleotide Variation
Frequency: T=0.003030 (802/264690, TOPMED)
T=0.005250 (1308/249146, GnomAD_exome)
T=0.003031 (663/218756, ALFA) (+ 19 more)
T=0.002246 (315/140256, GnomAD)
T=0.005288 (638/120656, ExAC)
T=0.00748 (589/78702, PAGE_STUDY)
T=0.06416 (1813/28258, 14KJPN)
T=0.06366 (1067/16760, 8.3KJPN)
T=0.00033 (4/12130, GO-ESP)
T=0.0153 (98/6404, 1000G_30x)
T=0.0148 (74/5008, 1000G)
T=0.0036 (16/4480, Estonian)
T=0.0005 (2/3854, ALSPAC)
T=0.0000 (0/3708, TWINSUK)
T=0.0914 (267/2922, KOREAN)
T=0.0797 (146/1832, Korea1K)
T=0.077 (61/792, PRJEB37584)
T=0.021 (13/614, Vietnamese)
T=0.005 (3/600, NorthernSweden)
T=0.007 (2/300, FINRISK)
C=0.50 (10/20, SGDP_PRJ)
T=0.50 (10/20, SGDP_PRJ)

Clinical Significance: Reported in ClinVar
Gene : Consequence: ACAN : Missense Variant
Publications: 0 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20230706150541

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	235258	C=0.997139	T=0.002861
European	Sub	196092	C=0.999490	T=0.000510
African	Sub	10286	C=0.99942	T=0.00058
African Others	Sub	370	C=1.000	T=0.000
African American	Sub	9916	C=0.9994	T=0.0006
Asian	Sub	6376	C=0.9311	T=0.0689
East Asian	Sub	4522	C=0.9244	T=0.0756
Other Asian	Sub	1854	C=0.9477	T=0.0523
Latin American 1	Sub	830	C=1.000	T=0.000
Latin American 2	Sub	1076	C=0.9981	T=0.0019
South Asian	Sub	312	C=1.000	T=0.000
Other	Sub	20286	C=0.99379	T=0.00621

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	C=0.996970	T=0.003030
gnomAD - Exomes	Global	Study-wide	249146	C=0.994750	T=0.005250
gnomAD - Exomes	European	Sub	134458	C=0.998959	T=0.001041
gnomAD - Exomes	Asian	Sub	48578	C=0.97750	T=0.02250
gnomAD - Exomes	American	Sub	34520	C=0.99864	T=0.00136
gnomAD - Exomes	African	Sub	15478	C=0.99987	T=0.00013
gnomAD - Exomes	Ashkenazi Jewish	Sub	10062	C=0.99901	T=0.00099
gnomAD - Exomes	Other	Sub	6050	C=0.9974	T=0.0026
Allele Frequency Aggregator	Total	Global	218756	C=0.996969	T=0.003031
Allele Frequency Aggregator	European	Sub	185880	C=0.999494	T=0.000506
Allele Frequency Aggregator	Other	Sub	18834	C=0.99336	T=0.00664
Allele Frequency Aggregator	Asian	Sub	6376	C=0.9311	T=0.0689
Allele Frequency Aggregator	African	Sub	5448	C=0.9994	T=0.0006
Allele Frequency Aggregator	Latin American 2	Sub	1076	C=0.9981	T=0.0019
Allele Frequency Aggregator	Latin American 1	Sub	830	C=1.000	T=0.000
Allele Frequency Aggregator	South Asian	Sub	312	C=1.000	T=0.000
gnomAD - Genomes	Global	Study-wide	140256	C=0.997754	T=0.002246
gnomAD - Genomes	European	Sub	75960	C=0.99883	T=0.00117
gnomAD - Genomes	African	Sub	42026	C=0.99979	T=0.00021
gnomAD - Genomes	American	Sub	13664	C=0.99912	T=0.00088
gnomAD - Genomes	Ashkenazi Jewish	Sub	3322	C=0.9997	T=0.0003
gnomAD - Genomes	East Asian	Sub	3132	C=0.9384	T=0.0616
gnomAD - Genomes	Other	Sub	2152	C=0.9949	T=0.0051
ExAC	Global	Study-wide	120656	C=0.994712	T=0.005288
ExAC	Europe	Sub	73296	C=0.99904	T=0.00096
ExAC	Asian	Sub	25126	C=0.97859	T=0.02141
ExAC	American	Sub	11554	C=0.99810	T=0.00190
ExAC	African	Sub	9782	C=0.9999	T=0.0001
ExAC	Other	Sub	898	C=0.992	T=0.008
The PAGE Study	Global	Study-wide	78702	C=0.99252	T=0.00748
The PAGE Study	AfricanAmerican	Sub	32516	C=0.99972	T=0.00028
The PAGE Study	Mexican	Sub	10810	C=0.99787	T=0.00213
The PAGE Study	Asian	Sub	8318	C=0.9412	T=0.0588
The PAGE Study	PuertoRican	Sub	7918	C=1.0000	T=0.0000
The PAGE Study	NativeHawaiian	Sub	4534	C=0.9907	T=0.0093
The PAGE Study	Cuban	Sub	4230	C=0.9998	T=0.0002
The PAGE Study	Dominican	Sub	3828	C=1.0000	T=0.0000
The PAGE Study	CentralAmerican	Sub	2450	C=0.9996	T=0.0004
The PAGE Study	SouthAmerican	Sub	1982	C=0.9934	T=0.0066
The PAGE Study	NativeAmerican	Sub	1260	C=0.9960	T=0.0040
The PAGE Study	SouthAsian	Sub	856	C=0.993	T=0.007
14KJPN	JAPANESE	Study-wide	28258	C=0.93584	T=0.06416
8.3KJPN	JAPANESE	Study-wide	16760	C=0.93634	T=0.06366
GO Exome Sequencing Project	Global	Study-wide	12130	C=0.99967	T=0.00033
GO Exome Sequencing Project	European American	Sub	8276	C=0.9995	T=0.0005
GO Exome Sequencing Project	African American	Sub	3854	C=1.0000	T=0.0000
1000Genomes_30x	Global	Study-wide	6404	C=0.9847	T=0.0153
1000Genomes_30x	African	Sub	1786	C=1.0000	T=0.0000
1000Genomes_30x	Europe	Sub	1266	C=0.9984	T=0.0016
1000Genomes_30x	South Asian	Sub	1202	C=0.9967	T=0.0033
1000Genomes_30x	East Asian	Sub	1170	C=0.9265	T=0.0735
1000Genomes_30x	American	Sub	980	C=0.994	T=0.006
1000Genomes	Global	Study-wide	5008	C=0.9852	T=0.0148
1000Genomes	African	Sub	1322	C=1.0000	T=0.0000
1000Genomes	East Asian	Sub	1008	C=0.9345	T=0.0655
1000Genomes	Europe	Sub	1006	C=0.9990	T=0.0010
1000Genomes	South Asian	Sub	978	C=0.997	T=0.003
1000Genomes	American	Sub	694	C=0.994	T=0.006
Genetic variation in the Estonian population	Estonian	Study-wide	4480	C=0.9964	T=0.0036
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.9995	T=0.0005
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=1.0000	T=0.0000
KOREAN population from KRGDB	KOREAN	Study-wide	2922	C=0.9086	T=0.0914
Korean Genome Project	KOREAN	Study-wide	1832	C=0.9203	T=0.0797
CNV burdens in cranial meningiomas	Global	Study-wide	792	C=0.923	T=0.077
CNV burdens in cranial meningiomas	CRM	Sub	792	C=0.923	T=0.077
A Vietnamese Genetic Variation Database	Global	Study-wide	614	C=0.979	T=0.021
Northern Sweden	ACPOP	Study-wide	600	C=0.995	T=0.005
FINRISK	Finnish from FINRISK project	Study-wide	300	C=0.993	T=0.007
SGDP_PRJ	Global	Study-wide	20	C=0.50	T=0.50

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 15	NC_000015.10:g.88858148C>T
GRCh37.p13 chr 15	NC_000015.9:g.89401379C>T
ACAN RefSeqGene	NG_012794.1:g.59706C>T

Gene: ACAN, aggrecan (plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ACAN transcript variant 3	NM_001369268.1:c.5563C>T	L [CTC] > F [TTC]	Coding Sequence Variant
aggrecan core protein isoform 3 precursor	NP_001356197.1:p.Leu1855P… NP_001356197.1:p.Leu1855Phe	L (Leu) > F (Phe)	Missense Variant
ACAN transcript variant 2	NM_013227.4:c.5563C>T	L [CTC] > F [TTC]	Coding Sequence Variant
aggrecan core protein isoform 2 precursor	NP_037359.3:p.Leu1855Phe	L (Leu) > F (Phe)	Missense Variant
ACAN transcript variant 1	NM_001135.4:c.5563C>T	L [CTC] > F [TTC]	Coding Sequence Variant
aggrecan core protein isoform 1 precursor	NP_001126.3:p.Leu1855Phe	L (Leu) > F (Phe)	Missense Variant
ACAN transcript variant X1	XM_047432214.1:c.5563C>T	L [CTC] > F [TTC]	Coding Sequence Variant
aggrecan core protein isoform X1	XP_047288170.1:p.Leu1855P… XP_047288170.1:p.Leu1855Phe	L (Leu) > F (Phe)	Missense Variant
ACAN transcript variant X2	XM_047432215.1:c.5563C>T	L [CTC] > F [TTC]	Coding Sequence Variant
aggrecan core protein isoform X2	XP_047288171.1:p.Leu1855P… XP_047288171.1:p.Leu1855Phe	L (Leu) > F (Phe)	Missense Variant
ACAN transcript variant X3	XM_011521313.2:c.5563C>T	L [CTC] > F [TTC]	Coding Sequence Variant
aggrecan core protein isoform X3	XP_011519615.1:p.Leu1855P… XP_011519615.1:p.Leu1855Phe	L (Leu) > F (Phe)	Missense Variant
ACAN transcript variant X3	XM_047432216.1:c.5563C>T	L [CTC] > F [TTC]	Coding Sequence Variant
aggrecan core protein isoform X3	XP_047288172.1:p.Leu1855P… XP_047288172.1:p.Leu1855Phe	L (Leu) > F (Phe)	Missense Variant
ACAN transcript variant X4	XM_047432217.1:c.5563C>T	L [CTC] > F [TTC]	Coding Sequence Variant
aggrecan core protein isoform X3	XP_047288173.1:p.Leu1855P… XP_047288173.1:p.Leu1855Phe	L (Leu) > F (Phe)	Missense Variant
ACAN transcript variant X6	XM_011521314.2:c.5563C>T	L [CTC] > F [TTC]	Coding Sequence Variant
aggrecan core protein isoform X5	XP_011519616.1:p.Leu1855P… XP_011519616.1:p.Leu1855Phe	L (Leu) > F (Phe)	Missense Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: T (allele ID: 1255545 )

ClinVar Accession	Disease Names	Clinical Significance
RCV001676332.2	not provided	Benign

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	C=	T
GRCh38.p14 chr 15	NC_000015.10:g.88858148=	NC_000015.10:g.88858148C>T
GRCh37.p13 chr 15	NC_000015.9:g.89401379=	NC_000015.9:g.89401379C>T
ACAN RefSeqGene	NG_012794.1:g.59706=	NG_012794.1:g.59706C>T
ACAN transcript variant 2	NM_013227.4:c.5563=	NM_013227.4:c.5563C>T
ACAN transcript variant 2	NM_013227.3:c.5563=	NM_013227.3:c.5563C>T
ACAN transcript variant 1	NM_001135.4:c.5563=	NM_001135.4:c.5563C>T
ACAN transcript variant 1	NM_001135.3:c.5563=	NM_001135.3:c.5563C>T
ACAN transcript variant 3	NM_001369268.1:c.5563=	NM_001369268.1:c.5563C>T
ACAN transcript variant X3	XM_011521313.2:c.5563=	XM_011521313.2:c.5563C>T
ACAN transcript variant X6	XM_011521314.2:c.5563=	XM_011521314.2:c.5563C>T
ACAN transcript variant 5	NM_001411097.1:c.5563=	NM_001411097.1:c.5563C>T
ACAN transcript variant 4	NM_001411096.1:c.5563=	NM_001411096.1:c.5563C>T
ACAN transcript variant X3	XM_047432216.1:c.5563=	XM_047432216.1:c.5563C>T
ACAN transcript variant X1	XM_047432214.1:c.5563=	XM_047432214.1:c.5563C>T
ACAN transcript variant X2	XM_047432215.1:c.5563=	XM_047432215.1:c.5563C>T
ACAN transcript variant X4	XM_047432217.1:c.5563=	XM_047432217.1:c.5563C>T
aggrecan core protein isoform 2 precursor	NP_037359.3:p.Leu1855=	NP_037359.3:p.Leu1855Phe
aggrecan core protein isoform 1 precursor	NP_001126.3:p.Leu1855=	NP_001126.3:p.Leu1855Phe
aggrecan core protein isoform 3 precursor	NP_001356197.1:p.Leu1855=	NP_001356197.1:p.Leu1855Phe
aggrecan core protein isoform X3	XP_011519615.1:p.Leu1855=	XP_011519615.1:p.Leu1855Phe
aggrecan core protein isoform X5	XP_011519616.1:p.Leu1855=	XP_011519616.1:p.Leu1855Phe
aggrecan core protein isoform X3	XP_047288172.1:p.Leu1855=	XP_047288172.1:p.Leu1855Phe
aggrecan core protein isoform X1	XP_047288170.1:p.Leu1855=	XP_047288170.1:p.Leu1855Phe
aggrecan core protein isoform X2	XP_047288171.1:p.Leu1855=	XP_047288171.1:p.Leu1855Phe
aggrecan core protein isoform X3	XP_047288173.1:p.Leu1855=	XP_047288173.1:p.Leu1855Phe

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

77 SubSNP, 21 Frequency, 1 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	ILLUMINA	ss161053176	Dec 01, 2009 (131)
2	1000GENOMES	ss243241491	Jul 15, 2010 (132)
3	GMI	ss282355142	May 04, 2012 (137)
4	ILLUMINA	ss479265743	Sep 08, 2015 (146)
5	ILLUMINA	ss482012439	May 04, 2012 (137)
6	ILLUMINA	ss483451645	May 04, 2012 (137)
7	EXOME_CHIP	ss491499075	May 04, 2012 (137)
8	ILLUMINA	ss534468599	Sep 08, 2015 (146)
9	SSMP	ss660380223	Apr 25, 2013 (138)
10	NHLBI-ESP	ss713253343	Apr 25, 2013 (138)
11	ILLUMINA	ss779326386	Sep 08, 2015 (146)
12	ILLUMINA	ss780712210	Sep 08, 2015 (146)
13	ILLUMINA	ss781625445	Sep 08, 2015 (146)
14	ILLUMINA	ss783387101	Sep 08, 2015 (146)
15	ILLUMINA	ss834794060	Sep 08, 2015 (146)
16	1000GENOMES	ss1354528486	Aug 21, 2014 (142)
17	EVA_FINRISK	ss1584096049	Apr 01, 2015 (144)
18	EVA_UK10K_ALSPAC	ss1633567339	Apr 01, 2015 (144)
19	EVA_UK10K_TWINSUK	ss1676561372	Apr 01, 2015 (144)
20	EVA_EXAC	ss1691982406	Apr 01, 2015 (144)
21	ILLUMINA	ss1752176110	Sep 08, 2015 (146)
22	ILLUMINA	ss1917900343	Feb 12, 2016 (147)
23	ILLUMINA	ss1946401516	Feb 12, 2016 (147)
24	ILLUMINA	ss1959635189	Feb 12, 2016 (147)
25	JJLAB	ss2028514161	Sep 14, 2016 (149)
26	HUMAN_LONGEVITY	ss2208933695	Dec 20, 2016 (150)
27	SYSTEMSBIOZJU	ss2628751740	Nov 08, 2017 (151)
28	ILLUMINA	ss2633263632	Nov 08, 2017 (151)
29	GRF	ss2701408771	Nov 08, 2017 (151)
30	GNOMAD	ss2741488633	Nov 08, 2017 (151)
31	GNOMAD	ss2749378739	Nov 08, 2017 (151)
32	GNOMAD	ss2937963564	Nov 08, 2017 (151)
33	AFFY	ss2985050500	Nov 08, 2017 (151)
34	SWEGEN	ss3013717887	Nov 08, 2017 (151)
35	ILLUMINA	ss3021658739	Nov 08, 2017 (151)
36	ILLUMINA	ss3627424537	Oct 12, 2018 (152)
37	ILLUMINA	ss3627424538	Oct 12, 2018 (152)
38	ILLUMINA	ss3631254082	Oct 12, 2018 (152)
39	ILLUMINA	ss3634619764	Oct 12, 2018 (152)
40	ILLUMINA	ss3636310648	Oct 12, 2018 (152)
41	ILLUMINA	ss3640327084	Oct 12, 2018 (152)
42	ILLUMINA	ss3644654624	Oct 12, 2018 (152)
43	ILLUMINA	ss3652061475	Oct 12, 2018 (152)
44	ILLUMINA	ss3653822469	Oct 12, 2018 (152)
45	EGCUT_WGS	ss3680849204	Jul 13, 2019 (153)
46	EVA_DECODE	ss3698415970	Jul 13, 2019 (153)
47	ILLUMINA	ss3725522664	Jul 13, 2019 (153)
48	ACPOP	ss3741151296	Jul 13, 2019 (153)
49	ILLUMINA	ss3744424411	Jul 13, 2019 (153)
50	ILLUMINA	ss3744920293	Jul 13, 2019 (153)
51	EVA	ss3753418791	Jul 13, 2019 (153)
52	PAGE_CC	ss3771848510	Jul 13, 2019 (153)
53	ILLUMINA	ss3772418793	Jul 13, 2019 (153)
54	KHV_HUMAN_GENOMES	ss3818719546	Jul 13, 2019 (153)
55	EVA	ss3824950989	Apr 27, 2020 (154)
56	EVA	ss3825865680	Apr 27, 2020 (154)
57	SGDP_PRJ	ss3883478435	Apr 27, 2020 (154)
58	KRGDB	ss3932726767	Apr 27, 2020 (154)
59	KOGIC	ss3976693278	Apr 27, 2020 (154)
60	EVA	ss3984705714	Apr 26, 2021 (155)
61	EVA	ss3986068419	Apr 26, 2021 (155)
62	EVA	ss3986661283	Apr 26, 2021 (155)
63	TOPMED	ss5000747487	Apr 26, 2021 (155)
64	TOMMO_GENOMICS	ss5217447799	Apr 26, 2021 (155)
65	EVA	ss5236926884	Apr 26, 2021 (155)
66	1000G_HIGH_COVERAGE	ss5299380362	Oct 16, 2022 (156)
67	TRAN_CS_UWATERLOO	ss5314442084	Oct 16, 2022 (156)
68	EVA	ss5315804606	Oct 16, 2022 (156)
69	EVA	ss5420950515	Oct 16, 2022 (156)
70	HUGCELL_USP	ss5492999220	Oct 16, 2022 (156)
71	1000G_HIGH_COVERAGE	ss5601254193	Oct 16, 2022 (156)
72	SANFORD_IMAGENETICS	ss5658035910	Oct 16, 2022 (156)
73	TOMMO_GENOMICS	ss5771632133	Oct 16, 2022 (156)
74	YY_MCH	ss5815569826	Oct 16, 2022 (156)
75	EVA	ss5847753491	Oct 16, 2022 (156)
76	EVA	ss5876947953	Oct 16, 2022 (156)
77	EVA	ss5949458350	Oct 16, 2022 (156)
78	1000Genomes	NC_000015.9 - 89401379	Oct 12, 2018 (152)
79	1000Genomes_30x	NC_000015.10 - 88858148	Oct 16, 2022 (156)
80	The Avon Longitudinal Study of Parents and Children	NC_000015.9 - 89401379	Oct 12, 2018 (152)
81	Genetic variation in the Estonian population	NC_000015.9 - 89401379	Oct 12, 2018 (152)
82	ExAC	NC_000015.9 - 89401379	Oct 12, 2018 (152)
83	FINRISK	NC_000015.9 - 89401379	Apr 27, 2020 (154)
84	gnomAD - Genomes	NC_000015.10 - 88858148	Apr 26, 2021 (155)
85	gnomAD - Exomes	NC_000015.9 - 89401379	Jul 13, 2019 (153)
86	GO Exome Sequencing Project	NC_000015.9 - 89401379	Oct 12, 2018 (152)
87	KOREAN population from KRGDB	NC_000015.9 - 89401379	Apr 27, 2020 (154)
88	Korean Genome Project	NC_000015.10 - 88858148	Apr 27, 2020 (154)
89	Northern Sweden	NC_000015.9 - 89401379	Jul 13, 2019 (153)
90	The PAGE Study	NC_000015.10 - 88858148	Jul 13, 2019 (153)
91	CNV burdens in cranial meningiomas	NC_000015.9 - 89401379	Apr 26, 2021 (155)
92	SGDP_PRJ	NC_000015.9 - 89401379	Apr 27, 2020 (154)
93	8.3KJPN	NC_000015.9 - 89401379	Apr 26, 2021 (155)
94	14KJPN	NC_000015.10 - 88858148	Oct 16, 2022 (156)
95	TopMed	NC_000015.10 - 88858148	Apr 26, 2021 (155)
96	UK 10K study - Twins	NC_000015.9 - 89401379	Oct 12, 2018 (152)
97	A Vietnamese Genetic Variation Database	NC_000015.9 - 89401379	Jul 13, 2019 (153)
98	ALFA	NC_000015.10 - 88858148	Apr 26, 2021 (155)
99	ClinVar	RCV001676332.2	Oct 16, 2022 (156)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss282355142, ss483451645	NC_000015.8:87202382:C:T	NC_000015.10:88858147:C:T	(self)
67637963, 37562584, 26587452, 2367474, 92510, 10756659, 1408232, 39904161, 14436161, 255242, 35495415, 75417106, 37562584, 8350073, ss243241491, ss479265743, ss482012439, ss491499075, ss534468599, ss660380223, ss713253343, ss779326386, ss780712210, ss781625445, ss783387101, ss834794060, ss1354528486, ss1584096049, ss1633567339, ss1676561372, ss1691982406, ss1752176110, ss1917900343, ss1946401516, ss1959635189, ss2028514161, ss2628751740, ss2633263632, ss2701408771, ss2741488633, ss2749378739, ss2937963564, ss2985050500, ss3013717887, ss3021658739, ss3627424537, ss3627424538, ss3631254082, ss3634619764, ss3636310648, ss3640327084, ss3644654624, ss3652061475, ss3653822469, ss3680849204, ss3741151296, ss3744424411, ss3744920293, ss3753418791, ss3772418793, ss3824950989, ss3825865680, ss3883478435, ss3932726767, ss3984705714, ss3986068419, ss3986661283, ss5217447799, ss5315804606, ss5420950515, ss5658035910, ss5847753491, ss5949458350	NC_000015.9:89401378:C:T	NC_000015.10:88858147:C:T	(self)
RCV001676332.2, 88780128, 476875324, 33071279, 1069979, 105469237, 216293147, 7877244385, ss2208933695, ss3698415970, ss3725522664, ss3771848510, ss3818719546, ss3976693278, ss5000747487, ss5236926884, ss5299380362, ss5314442084, ss5492999220, ss5601254193, ss5771632133, ss5815569826, ss5876947953	NC_000015.10:88858147:C:T	NC_000015.10:88858147:C:T	(self)
ss161053176	NT_010274.17:4366905:C:T	NC_000015.10:88858147:C:T	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

No publications for rs74505897

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

Select flank length:

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Choose placement

dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs74505897