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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs2240758

Current Build 156

Released September 21, 2022

Organism
Homo sapiens
Position
chr17:46171133 (GRCh38.p14) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
G>A / G>C / G>T
Variation Type
SNV Single Nucleotide Variation
Frequency
C=0.153867 (40727/264690, TOPMED)
C=0.217527 (54628/251132, GnomAD_exome)
C=0.149283 (20853/139688, GnomAD) (+ 21 more)
C=0.210458 (25542/121364, ExAC)
C=0.13086 (6203/47400, ALFA)
C=0.48786 (13786/28258, 14KJPN)
C=0.49183 (8243/16760, 8.3KJPN)
C=0.12379 (1610/13006, GO-ESP)
C=0.1916 (1227/6404, 1000G_30x)
C=0.1911 (957/5008, 1000G)
C=0.2080 (932/4480, Estonian)
C=0.1767 (681/3854, ALSPAC)
C=0.1796 (666/3708, TWINSUK)
G=0.4669 (1368/2930, KOREAN)
C=0.176 (176/998, GoNL)
C=0.322 (198/614, Vietnamese)
C=0.210 (126/600, NorthernSweden)
C=0.125 (67/534, MGP)
C=0.222 (71/320, HapMap)
C=0.265 (80/302, FINRISK)
C=0.032 (7/216, Qatari)
G=0.361 (78/216, SGDP_PRJ)
C=0.10 (4/40, GENOME_DK)
G=0.36 (13/36, Siberian)
Clinical Significance
Reported in ClinVar
Gene : Consequence
KANSL1 : Synonymous Variant
Publications
0 citations
Genomic View
See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20230706150541
Population Group Sample Size Ref Allele Alt Allele
Total Global 47400 G=0.86914 A=0.00000, C=0.13086, T=0.00000
European Sub 36170 G=0.85911 A=0.00000, C=0.14089, T=0.00000
African Sub 3386 G=0.9829 A=0.0000, C=0.0171, T=0.0000
African Others Sub 120 G=1.000 A=0.000, C=0.000, T=0.000
African American Sub 3266 G=0.9822 A=0.0000, C=0.0178, T=0.0000
Asian Sub 88 G=0.72 A=0.00, C=0.28, T=0.00
East Asian Sub 46 G=0.70 A=0.00, C=0.30, T=0.00
Other Asian Sub 42 G=0.74 A=0.00, C=0.26, T=0.00
Latin American 1 Sub 462 G=0.937 A=0.000, C=0.063, T=0.000
Latin American 2 Sub 268 G=0.993 A=0.000, C=0.007, T=0.000
South Asian Sub 70 G=0.99 A=0.00, C=0.01, T=0.00
Other Sub 6956 G=0.8574 A=0.0000, C=0.1426, T=0.0000


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 G=0.846133 C=0.153867
gnomAD - Exomes Global Study-wide 251132 G=0.782473 C=0.217527
gnomAD - Exomes European Sub 135146 G=0.805706 C=0.194294
gnomAD - Exomes Asian Sub 48968 G=0.74600 C=0.25400
gnomAD - Exomes American Sub 34562 G=0.61874 C=0.38126
gnomAD - Exomes African Sub 16254 G=0.96850 C=0.03150
gnomAD - Exomes Ashkenazi Jewish Sub 10068 G=0.89303 C=0.10697
gnomAD - Exomes Other Sub 6134 G=0.8099 C=0.1901
gnomAD - Genomes Global Study-wide 139688 G=0.850717 C=0.149283
gnomAD - Genomes European Sub 75570 G=0.81382 C=0.18618
gnomAD - Genomes African Sub 41990 G=0.96587 C=0.03413
gnomAD - Genomes American Sub 13554 G=0.75203 C=0.24797
gnomAD - Genomes Ashkenazi Jewish Sub 3316 G=0.8881 C=0.1119
gnomAD - Genomes East Asian Sub 3114 G=0.5870 C=0.4130
gnomAD - Genomes Other Sub 2144 G=0.8451 C=0.1549
ExAC Global Study-wide 121364 G=0.789542 C=0.210458
ExAC Europe Sub 73330 G=0.80967 C=0.19033
ExAC Asian Sub 25158 G=0.74863 C=0.25137
ExAC American Sub 11564 G=0.58855 C=0.41145
ExAC African Sub 10404 G=0.96857 C=0.03143
ExAC Other Sub 908 G=0.806 C=0.194
Allele Frequency Aggregator Total Global 47400 G=0.86914 A=0.00000, C=0.13086, T=0.00000
Allele Frequency Aggregator European Sub 36170 G=0.85911 A=0.00000, C=0.14089, T=0.00000
Allele Frequency Aggregator Other Sub 6956 G=0.8574 A=0.0000, C=0.1426, T=0.0000
Allele Frequency Aggregator African Sub 3386 G=0.9829 A=0.0000, C=0.0171, T=0.0000
Allele Frequency Aggregator Latin American 1 Sub 462 G=0.937 A=0.000, C=0.063, T=0.000
Allele Frequency Aggregator Latin American 2 Sub 268 G=0.993 A=0.000, C=0.007, T=0.000
Allele Frequency Aggregator Asian Sub 88 G=0.72 A=0.00, C=0.28, T=0.00
Allele Frequency Aggregator South Asian Sub 70 G=0.99 A=0.00, C=0.01, T=0.00
14KJPN JAPANESE Study-wide 28258 G=0.51214 C=0.48786
8.3KJPN JAPANESE Study-wide 16760 G=0.50817 C=0.49183
GO Exome Sequencing Project Global Study-wide 13006 G=0.87621 C=0.12379
GO Exome Sequencing Project European American Sub 8600 G=0.8324 C=0.1676
GO Exome Sequencing Project African American Sub 4406 G=0.9616 C=0.0384
1000Genomes_30x Global Study-wide 6404 G=0.8084 C=0.1916
1000Genomes_30x African Sub 1786 G=0.9922 C=0.0078
1000Genomes_30x Europe Sub 1266 G=0.8041 C=0.1959
1000Genomes_30x South Asian Sub 1202 G=0.8544 C=0.1456
1000Genomes_30x East Asian Sub 1170 G=0.5889 C=0.4111
1000Genomes_30x American Sub 980 G=0.685 C=0.315
1000Genomes Global Study-wide 5008 G=0.8089 C=0.1911
1000Genomes African Sub 1322 G=0.9924 C=0.0076
1000Genomes East Asian Sub 1008 G=0.5903 C=0.4097
1000Genomes Europe Sub 1006 G=0.8072 C=0.1928
1000Genomes South Asian Sub 978 G=0.863 C=0.137
1000Genomes American Sub 694 G=0.703 C=0.297
Genetic variation in the Estonian population Estonian Study-wide 4480 G=0.7920 C=0.2080
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 G=0.8233 C=0.1767
UK 10K study - Twins TWIN COHORT Study-wide 3708 G=0.8204 C=0.1796
KOREAN population from KRGDB KOREAN Study-wide 2930 G=0.4669 C=0.5331, T=0.0000
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 G=0.824 C=0.176
A Vietnamese Genetic Variation Database Global Study-wide 614 G=0.678 C=0.322
Northern Sweden ACPOP Study-wide 600 G=0.790 C=0.210
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 G=0.875 C=0.125
HapMap Global Study-wide 320 G=0.778 C=0.222
HapMap African Sub 118 G=1.000 C=0.000
HapMap American Sub 116 G=0.767 C=0.233
HapMap Asian Sub 86 G=0.49 C=0.51
FINRISK Finnish from FINRISK project Study-wide 302 G=0.735 C=0.265
Qatari Global Study-wide 216 G=0.968 C=0.032
SGDP_PRJ Global Study-wide 216 G=0.361 C=0.639
The Danish reference pan genome Danish Study-wide 40 G=0.90 C=0.10
Siberian Global Study-wide 36 G=0.36 C=0.64
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p14 chr 17 NC_000017.11:g.46171133G>A
GRCh38.p14 chr 17 NC_000017.11:g.46171133G>C
GRCh38.p14 chr 17 NC_000017.11:g.46171133G>T
GRCh37.p13 chr 17 NC_000017.10:g.44248499G>A
GRCh37.p13 chr 17 NC_000017.10:g.44248499G>C
GRCh37.p13 chr 17 NC_000017.10:g.44248499G>T
KANSL1 RefSeqGene NG_032784.1:g.59242C>T
KANSL1 RefSeqGene NG_032784.1:g.59242C>G
KANSL1 RefSeqGene NG_032784.1:g.59242C>A
GRCh38.p14 chr 17 alt locus HSCHR17_2_CTG5 NT_187663.1:g.873238G>A
GRCh38.p14 chr 17 alt locus HSCHR17_2_CTG5 NT_187663.1:g.873238G>C
GRCh38.p14 chr 17 alt locus HSCHR17_2_CTG5 NT_187663.1:g.873238G>T
GRCh38.p14 chr 17 alt locus HSCHR17_1_CTG5 NT_167251.2:g.615851C>T
GRCh38.p14 chr 17 alt locus HSCHR17_1_CTG5 NT_167251.2:g.615851C>G
GRCh38.p14 chr 17 alt locus HSCHR17_1_CTG5 NT_167251.2:g.615851C>A
GRCh37.p13 chr 17 alt locus HSCHR17_1_CTG5 NT_167251.1:g.617844C>T
GRCh37.p13 chr 17 alt locus HSCHR17_1_CTG5 NT_167251.1:g.617844C>G
GRCh37.p13 chr 17 alt locus HSCHR17_1_CTG5 NT_167251.1:g.617844C>A
Gene: KANSL1, KAT8 regulatory NSL complex subunit 1 (minus strand)
Molecule type Change Amino acid[Codon] SO Term
KANSL1 transcript variant 1 NM_001193466.2:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_001180395.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 1 NM_001193466.2:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_001180395.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 1 NM_001193466.2:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_001180395.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 2 NM_015443.4:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_056258.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 2 NM_015443.4:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_056258.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 2 NM_015443.4:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_056258.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 3 NM_001193465.2:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 2 NP_001180394.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 3 NM_001193465.2:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 2 NP_001180394.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 3 NM_001193465.2:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 2 NP_001180394.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 4 NM_001379198.1:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_001366127.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 4 NM_001379198.1:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_001366127.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant 4 NM_001379198.1:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_001366127.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X4 XM_047435801.1:c.-269= N/A 5 Prime UTR Variant
KANSL1 transcript variant X1 XM_006721824.5:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X1 XP_006721887.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X1 XM_006721824.5:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X1 XP_006721887.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X1 XM_006721824.5:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X1 XP_006721887.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X1 XM_047435794.1:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X1 XP_047291750.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X1 XM_047435794.1:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X1 XP_047291750.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X1 XM_047435794.1:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X1 XP_047291750.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X2 XM_011524628.4:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X2 XP_011522930.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X2 XM_011524628.4:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X2 XP_011522930.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X2 XM_011524628.4:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X2 XP_011522930.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X4 XM_047435795.1:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X2 XP_047291751.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X4 XM_047435795.1:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X2 XP_047291751.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X4 XM_047435795.1:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X2 XP_047291751.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X5 XM_047435796.1:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X3 XP_047291752.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X5 XM_047435796.1:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X3 XP_047291752.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X5 XM_047435796.1:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X3 XP_047291752.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X6 XM_047435797.1:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X4 XP_047291753.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X6 XM_047435797.1:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X4 XP_047291753.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X6 XM_047435797.1:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X4 XP_047291753.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X7 XM_047435798.1:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X5 XP_047291754.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X7 XM_047435798.1:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X5 XP_047291754.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X7 XM_047435798.1:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X5 XP_047291754.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X8 XM_017024488.3:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X6 XP_016879977.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X8 XM_017024488.3:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X6 XP_016879977.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X8 XM_017024488.3:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X6 XP_016879977.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X9 XM_047435799.1:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X5 XP_047291755.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X9 XM_047435799.1:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X5 XP_047291755.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X9 XM_047435799.1:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X5 XP_047291755.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X3 XM_047435800.1:c.1011C>T S [TCC] > S [TCT] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X3 XP_047291756.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X3 XM_047435800.1:c.1011C>G S [TCC] > S [TCG] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X3 XP_047291756.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
KANSL1 transcript variant X3 XM_047435800.1:c.1011C>A S [TCC] > S [TCA] Coding Sequence Variant
KAT8 regulatory NSL complex subunit 1 isoform X3 XP_047291756.1:p.Ser337= S (Ser) > S (Ser) Synonymous Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: C (allele ID: 328904 )
ClinVar Accession Disease Names Clinical Significance
RCV001514335.4 Koolen-de Vries syndrome Benign
RCV001528289.4 not specified Benign
RCV001598654.3 not provided Benign
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement G= A C T
GRCh38.p14 chr 17 NC_000017.11:g.46171133= NC_000017.11:g.46171133G>A NC_000017.11:g.46171133G>C NC_000017.11:g.46171133G>T
GRCh37.p13 chr 17 NC_000017.10:g.44248499= NC_000017.10:g.44248499G>A NC_000017.10:g.44248499G>C NC_000017.10:g.44248499G>T
KANSL1 RefSeqGene NG_032784.1:g.59242= NG_032784.1:g.59242C>T NG_032784.1:g.59242C>G NG_032784.1:g.59242C>A
KANSL1 transcript variant 2 NM_015443.4:c.1011= NM_015443.4:c.1011C>T NM_015443.4:c.1011C>G NM_015443.4:c.1011C>A
KANSL1 transcript variant 2 NM_015443.3:c.1011= NM_015443.3:c.1011C>T NM_015443.3:c.1011C>G NM_015443.3:c.1011C>A
KANSL1 transcript variant 1 NM_001193466.2:c.1011= NM_001193466.2:c.1011C>T NM_001193466.2:c.1011C>G NM_001193466.2:c.1011C>A
KANSL1 transcript variant 1 NM_001193466.1:c.1011= NM_001193466.1:c.1011C>T NM_001193466.1:c.1011C>G NM_001193466.1:c.1011C>A
KANSL1 transcript variant 3 NM_001193465.2:c.1011= NM_001193465.2:c.1011C>T NM_001193465.2:c.1011C>G NM_001193465.2:c.1011C>A
KANSL1 transcript variant 3 NM_001193465.1:c.1011= NM_001193465.1:c.1011C>T NM_001193465.1:c.1011C>G NM_001193465.1:c.1011C>A
KANSL1 transcript variant 8 NM_001405857.1:c.1011= NM_001405857.1:c.1011C>T NM_001405857.1:c.1011C>G NM_001405857.1:c.1011C>A
KANSL1 transcript variant 11 NM_001405860.1:c.1011= NM_001405860.1:c.1011C>T NM_001405860.1:c.1011C>G NM_001405860.1:c.1011C>A
KANSL1 transcript variant 14 NM_001405873.1:c.1011= NM_001405873.1:c.1011C>T NM_001405873.1:c.1011C>G NM_001405873.1:c.1011C>A
KANSL1 transcript variant 18 NM_001405877.1:c.1011= NM_001405877.1:c.1011C>T NM_001405877.1:c.1011C>G NM_001405877.1:c.1011C>A
KANSL1 transcript variant 21 NM_001405880.1:c.1011= NM_001405880.1:c.1011C>T NM_001405880.1:c.1011C>G NM_001405880.1:c.1011C>A
KANSL1 transcript variant 7 NM_001405856.1:c.1011= NM_001405856.1:c.1011C>T NM_001405856.1:c.1011C>G NM_001405856.1:c.1011C>A
KANSL1 transcript variant 5 NM_001405854.1:c.1011= NM_001405854.1:c.1011C>T NM_001405854.1:c.1011C>G NM_001405854.1:c.1011C>A
KANSL1 transcript variant 6 NM_001405855.1:c.1011= NM_001405855.1:c.1011C>T NM_001405855.1:c.1011C>G NM_001405855.1:c.1011C>A
KANSL1 transcript variant 9 NM_001405858.1:c.1011= NM_001405858.1:c.1011C>T NM_001405858.1:c.1011C>G NM_001405858.1:c.1011C>A
KANSL1 transcript variant 17 NM_001405876.1:c.1011= NM_001405876.1:c.1011C>T NM_001405876.1:c.1011C>G NM_001405876.1:c.1011C>A
KANSL1 transcript variant 15 NM_001405874.1:c.1011= NM_001405874.1:c.1011C>T NM_001405874.1:c.1011C>G NM_001405874.1:c.1011C>A
KANSL1 transcript variant 4 NM_001379198.1:c.1011= NM_001379198.1:c.1011C>T NM_001379198.1:c.1011C>G NM_001379198.1:c.1011C>A
KANSL1 transcript variant 19 NM_001405878.1:c.1011= NM_001405878.1:c.1011C>T NM_001405878.1:c.1011C>G NM_001405878.1:c.1011C>A
KANSL1 transcript variant 10 NM_001405859.1:c.1011= NM_001405859.1:c.1011C>T NM_001405859.1:c.1011C>G NM_001405859.1:c.1011C>A
KANSL1 transcript variant 12 NM_001405861.1:c.1011= NM_001405861.1:c.1011C>T NM_001405861.1:c.1011C>G NM_001405861.1:c.1011C>A
KANSL1 transcript variant 13 NM_001405872.1:c.1011= NM_001405872.1:c.1011C>T NM_001405872.1:c.1011C>G NM_001405872.1:c.1011C>A
KANSL1 transcript variant 16 NM_001405875.1:c.1011= NM_001405875.1:c.1011C>T NM_001405875.1:c.1011C>G NM_001405875.1:c.1011C>A
KANSL1 transcript variant 20 NM_001405879.1:c.1011= NM_001405879.1:c.1011C>T NM_001405879.1:c.1011C>G NM_001405879.1:c.1011C>A
KANSL1 transcript variant 22 NM_001405881.1:c.1011= NM_001405881.1:c.1011C>T NM_001405881.1:c.1011C>G NM_001405881.1:c.1011C>A
GRCh38.p14 chr 17 alt locus HSCHR17_2_CTG5 NT_187663.1:g.873238= NT_187663.1:g.873238G>A NT_187663.1:g.873238G>C NT_187663.1:g.873238G>T
GRCh38.p14 chr 17 alt locus HSCHR17_1_CTG5 NT_167251.2:g.615851= NT_167251.2:g.615851C>T NT_167251.2:g.615851C>G NT_167251.2:g.615851C>A
GRCh37.p13 chr 17 alt locus HSCHR17_1_CTG5 NT_167251.1:g.617844= NT_167251.1:g.617844C>T NT_167251.1:g.617844C>G NT_167251.1:g.617844C>A
KANSL1 transcript variant X1 XM_006721824.5:c.1011= XM_006721824.5:c.1011C>T XM_006721824.5:c.1011C>G XM_006721824.5:c.1011C>A
KANSL1 transcript variant X2 XM_011524628.4:c.1011= XM_011524628.4:c.1011C>T XM_011524628.4:c.1011C>G XM_011524628.4:c.1011C>A
KANSL1 transcript variant X3 XM_011524628.3:c.1011= XM_011524628.3:c.1011C>T XM_011524628.3:c.1011C>G XM_011524628.3:c.1011C>A
KANSL1 transcript variant X3 XM_011524628.2:c.1011= XM_011524628.2:c.1011C>T XM_011524628.2:c.1011C>G XM_011524628.2:c.1011C>A
KANSL1 transcript variant X3 XM_011524628.1:c.1011= XM_011524628.1:c.1011C>T XM_011524628.1:c.1011C>G XM_011524628.1:c.1011C>A
KANSL1 transcript variant X8 XM_017024488.3:c.1011= XM_017024488.3:c.1011C>T XM_017024488.3:c.1011C>G XM_017024488.3:c.1011C>A
KANSL1 transcript variant X4 XM_047435801.1:c.-269= XM_047435801.1:c.-269C>T XM_047435801.1:c.-269C>G XM_047435801.1:c.-269C>A
KANSL1 transcript variant X9 XM_047435799.1:c.1011= XM_047435799.1:c.1011C>T XM_047435799.1:c.1011C>G XM_047435799.1:c.1011C>A
KANSL1 transcript variant X7 XM_047435798.1:c.1011= XM_047435798.1:c.1011C>T XM_047435798.1:c.1011C>G XM_047435798.1:c.1011C>A
KANSL1 transcript variant X4 XM_047435795.1:c.1011= XM_047435795.1:c.1011C>T XM_047435795.1:c.1011C>G XM_047435795.1:c.1011C>A
KANSL1 transcript variant X1 XM_047435794.1:c.1011= XM_047435794.1:c.1011C>T XM_047435794.1:c.1011C>G XM_047435794.1:c.1011C>A
KANSL1 transcript variant X5 XM_047435796.1:c.1011= XM_047435796.1:c.1011C>T XM_047435796.1:c.1011C>G XM_047435796.1:c.1011C>A
KANSL1 transcript variant X6 XM_047435797.1:c.1011= XM_047435797.1:c.1011C>T XM_047435797.1:c.1011C>G XM_047435797.1:c.1011C>A
KANSL1 transcript variant X3 XM_047435800.1:c.1011= XM_047435800.1:c.1011C>T XM_047435800.1:c.1011C>G XM_047435800.1:c.1011C>A
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_056258.1:p.Ser337= NP_056258.1:p.Ser337= NP_056258.1:p.Ser337= NP_056258.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_001180395.1:p.Ser337= NP_001180395.1:p.Ser337= NP_001180395.1:p.Ser337= NP_001180395.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform 2 NP_001180394.1:p.Ser337= NP_001180394.1:p.Ser337= NP_001180394.1:p.Ser337= NP_001180394.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform 1 NP_001366127.1:p.Ser337= NP_001366127.1:p.Ser337= NP_001366127.1:p.Ser337= NP_001366127.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X1 XP_006721887.1:p.Ser337= XP_006721887.1:p.Ser337= XP_006721887.1:p.Ser337= XP_006721887.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X2 XP_011522930.1:p.Ser337= XP_011522930.1:p.Ser337= XP_011522930.1:p.Ser337= XP_011522930.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X6 XP_016879977.1:p.Ser337= XP_016879977.1:p.Ser337= XP_016879977.1:p.Ser337= XP_016879977.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X5 XP_047291755.1:p.Ser337= XP_047291755.1:p.Ser337= XP_047291755.1:p.Ser337= XP_047291755.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X5 XP_047291754.1:p.Ser337= XP_047291754.1:p.Ser337= XP_047291754.1:p.Ser337= XP_047291754.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X2 XP_047291751.1:p.Ser337= XP_047291751.1:p.Ser337= XP_047291751.1:p.Ser337= XP_047291751.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X1 XP_047291750.1:p.Ser337= XP_047291750.1:p.Ser337= XP_047291750.1:p.Ser337= XP_047291750.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X3 XP_047291752.1:p.Ser337= XP_047291752.1:p.Ser337= XP_047291752.1:p.Ser337= XP_047291752.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X4 XP_047291753.1:p.Ser337= XP_047291753.1:p.Ser337= XP_047291753.1:p.Ser337= XP_047291753.1:p.Ser337=
KAT8 regulatory NSL complex subunit 1 isoform X3 XP_047291756.1:p.Ser337= XP_047291756.1:p.Ser337= XP_047291756.1:p.Ser337= XP_047291756.1:p.Ser337=
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

88 SubSNP, 24 Frequency, 3 ClinVar submissions
No Submitter Submission ID Date (Build)
1 YUSUKE ss3196498 Aug 15, 2001 (98)
2 WI_SSAHASNP ss6613951 Sep 28, 2016 (150)
3 CSHL-HAPMAP ss20040830 Feb 12, 2016 (147)
4 SSAHASNP ss21425392 Feb 12, 2016 (147)
5 PERLEGEN ss24109002 Sep 20, 2004 (123)
6 ABI ss44011651 Mar 13, 2006 (126)
7 APPLERA_GI ss48425062 Mar 13, 2006 (126)
8 ILLUMINA ss65737906 Oct 16, 2006 (127)
9 HUMANGENOME_JCVI ss96596662 Feb 04, 2009 (130)
10 ENSEMBL ss136561544 Dec 01, 2009 (131)
11 GMI ss158054483 Dec 01, 2009 (131)
12 SEATTLESEQ ss159735654 Dec 01, 2009 (131)
13 ILLUMINA ss160520047 Dec 01, 2009 (131)
14 BUSHMAN ss202550020 Jul 04, 2010 (132)
15 1000GENOMES ss237252183 Feb 12, 2016 (147)
16 1000GENOMES ss243547027 Feb 12, 2016 (147)
17 GMI ss282773677 May 04, 2012 (137)
18 GMI ss287183998 Apr 25, 2013 (138)
19 PJP ss292056566 May 09, 2011 (137)
20 NHLBI-ESP ss342456922 Feb 12, 2016 (147)
21 ILLUMINA ss410920822 Sep 17, 2011 (137)
22 ILLUMINA ss481294533 Feb 12, 2016 (147)
23 ILLUMINA ss483589580 Feb 12, 2016 (147)
24 ILLUMINA ss483629863 May 04, 2012 (137)
25 1000GENOMES ss491125738 Feb 12, 2016 (147)
26 CLINSEQ_SNP ss491738369 May 04, 2012 (137)
27 ILLUMINA ss535795025 Feb 12, 2016 (147)
28 SSMP ss661091593 Feb 12, 2016 (147)
29 ILLUMINA ss779511232 Feb 12, 2016 (147)
30 ILLUMINA ss782238204 Feb 12, 2016 (147)
31 ILLUMINA ss834981594 Feb 12, 2016 (147)
32 EVA-GONL ss993132946 Feb 12, 2016 (147)
33 JMKIDD_LAB ss1067572369 Feb 12, 2016 (147)
34 JMKIDD_LAB ss1081074920 Feb 12, 2016 (147)
35 1000GENOMES ss1358754103 Feb 12, 2016 (147)
36 EVA_GENOME_DK ss1578167213 Feb 12, 2016 (147)
37 EVA_FINRISK ss1584106886 Feb 12, 2016 (147)
38 EVA_UK10K_ALSPAC ss1635700222 Feb 12, 2016 (147)
39 EVA_UK10K_TWINSUK ss1678694255 Feb 12, 2016 (147)
40 EVA_EXAC ss1692829501 Feb 12, 2016 (147)
41 EVA_DECODE ss1697176074 Apr 01, 2015 (144)
42 EVA_MGP ss1711463655 Feb 12, 2016 (147)
43 WEILL_CORNELL_DGM ss1936594022 Feb 12, 2016 (147)
44 GENOMED ss1968394321 Jul 19, 2016 (147)
45 JJLAB ss2029073675 Sep 14, 2016 (149)
46 USC_VALOUEV ss2157546783 Dec 20, 2016 (150)
47 HUMAN_LONGEVITY ss2217035922 Dec 20, 2016 (150)
48 SYSTEMSBIOZJU ss2629031839 Nov 08, 2017 (151)
49 ILLUMINA ss2633399513 Nov 08, 2017 (151)
50 GRF ss2702106752 Nov 08, 2017 (151)
51 GNOMAD ss2749798418 Nov 08, 2017 (151)
52 AFFY ss2985097821 Nov 08, 2017 (151)
53 SWEGEN ss3015578203 Nov 08, 2017 (151)
54 BIOINF_KMB_FNS_UNIBA ss3028358210 Nov 08, 2017 (151)
55 ILLUMINA ss3627675586 Oct 12, 2018 (152)
56 ILLUMINA ss3631380397 Oct 12, 2018 (152)
57 ILLUMINA ss3636366413 Oct 12, 2018 (152)
58 OMUKHERJEE_ADBS ss3646512565 Oct 12, 2018 (152)
59 URBANLAB ss3650660799 Oct 12, 2018 (152)
60 ILLUMINA ss3653869189 Oct 12, 2018 (152)
61 EGCUT_WGS ss3682460147 Jul 13, 2019 (153)
62 EVA_DECODE ss3700517862 Jul 13, 2019 (153)
63 ACPOP ss3742047622 Jul 13, 2019 (153)
64 EVA ss3754697076 Jul 13, 2019 (153)
65 KHV_HUMAN_GENOMES ss3819964838 Jul 13, 2019 (153)
66 EVA ss3825124292 Apr 27, 2020 (154)
67 EVA ss3825901347 Apr 27, 2020 (154)
68 EVA ss3834880941 Apr 27, 2020 (154)
69 SGDP_PRJ ss3885801915 Apr 27, 2020 (154)
70 KRGDB ss3935502031 Apr 27, 2020 (154)
71 EVA ss3986730612 Apr 27, 2021 (155)
72 TOPMED ss5036856521 Apr 27, 2021 (155)
73 TOMMO_GENOMICS ss5222540394 Apr 27, 2021 (155)
74 EVA ss5236943900 Apr 27, 2021 (155)
75 EVA ss5237669249 Oct 16, 2022 (156)
76 1000G_HIGH_COVERAGE ss5303223893 Oct 16, 2022 (156)
77 EVA ss5315888169 Oct 16, 2022 (156)
78 EVA ss5427754565 Oct 16, 2022 (156)
79 HUGCELL_USP ss5496267413 Oct 16, 2022 (156)
80 1000G_HIGH_COVERAGE ss5606985994 Oct 16, 2022 (156)
81 SANFORD_IMAGENETICS ss5660153031 Oct 16, 2022 (156)
82 TOMMO_GENOMICS ss5778791681 Oct 16, 2022 (156)
83 YY_MCH ss5816562251 Oct 16, 2022 (156)
84 EVA ss5834019275 Oct 16, 2022 (156)
85 EVA ss5848451400 Oct 16, 2022 (156)
86 EVA ss5851816601 Oct 16, 2022 (156)
87 EVA ss5936567972 Oct 16, 2022 (156)
88 EVA ss5951544465 Oct 16, 2022 (156)
89 1000Genomes NC_000017.10 - 44248499 Oct 12, 2018 (152)
90 1000Genomes_30x NC_000017.11 - 46171133 Oct 16, 2022 (156)
91 The Avon Longitudinal Study of Parents and Children NC_000017.10 - 44248499 Oct 12, 2018 (152)
92 Genetic variation in the Estonian population NC_000017.10 - 44248499 Oct 12, 2018 (152)
93 ExAC NC_000017.10 - 44248499 Oct 12, 2018 (152)
94 FINRISK NC_000017.10 - 44248499 Apr 27, 2020 (154)
95 The Danish reference pan genome NC_000017.10 - 44248499 Apr 27, 2020 (154)
96 gnomAD - Genomes NC_000017.11 - 46171133 Apr 27, 2021 (155)
97 gnomAD - Exomes NC_000017.10 - 44248499 Jul 13, 2019 (153)
98 GO Exome Sequencing Project NC_000017.10 - 44248499 Oct 12, 2018 (152)
99 Genome of the Netherlands Release 5 NC_000017.10 - 44248499 Apr 27, 2020 (154)
100 HapMap NC_000017.11 - 46171133 Apr 27, 2020 (154)
101 KOREAN population from KRGDB NC_000017.10 - 44248499 Apr 27, 2020 (154)
102 Medical Genome Project healthy controls from Spanish population NC_000017.10 - 44248499 Apr 27, 2020 (154)
103 Northern Sweden NC_000017.10 - 44248499 Jul 13, 2019 (153)
104 Qatari NC_000017.10 - 44248499 Apr 27, 2020 (154)
105 SGDP_PRJ NC_000017.10 - 44248499 Apr 27, 2020 (154)
106 Siberian NC_000017.10 - 44248499 Apr 27, 2020 (154)
107 8.3KJPN NC_000017.10 - 44248499 Apr 27, 2021 (155)
108 14KJPN NC_000017.11 - 46171133 Oct 16, 2022 (156)
109 TopMed NC_000017.11 - 46171133 Apr 27, 2021 (155)
110 UK 10K study - Twins NC_000017.10 - 44248499 Oct 12, 2018 (152)
111 A Vietnamese Genetic Variation Database NC_000017.10 - 44248499 Jul 13, 2019 (153)
112 ALFA NC_000017.11 - 46171133 Apr 27, 2021 (155)
113 ClinVar RCV001514335.4 Oct 16, 2022 (156)
114 ClinVar RCV001528289.4 Oct 16, 2022 (156)
115 ClinVar RCV001598654.3 Oct 16, 2022 (156)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs117366359 May 04, 2012 (137)
rs879952834 Dec 20, 2016 (150)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
8778547255 NC_000017.11:46171132:G:A NC_000017.11:46171132:G:A (self)
ss160520047, ss202550020, ss282773677, ss287183998, ss292056566, ss483629863, ss491738369, ss1697176074 NC_000017.9:41604275:G:C NC_000017.11:46171132:G:C (self)
71999657, 39901592, 28198395, 3276522, 103347, 4369157, 12102241, 1581370, 17783512, 42679425, 579415, 15332487, 18635944, 37818895, 10063137, 80509701, 39901592, 8827143, ss237252183, ss243547027, ss342456922, ss481294533, ss483589580, ss491125738, ss535795025, ss661091593, ss779511232, ss782238204, ss834981594, ss993132946, ss1067572369, ss1081074920, ss1358754103, ss1578167213, ss1584106886, ss1635700222, ss1678694255, ss1692829501, ss1711463655, ss1936594022, ss1968394321, ss2029073675, ss2157546783, ss2629031839, ss2633399513, ss2702106752, ss2749798418, ss2985097821, ss3015578203, ss3627675586, ss3631380397, ss3636366413, ss3646512565, ss3653869189, ss3682460147, ss3742047622, ss3754697076, ss3825124292, ss3825901347, ss3834880941, ss3885801915, ss3935502031, ss3986730612, ss5222540394, ss5315888169, ss5427754565, ss5660153031, ss5834019275, ss5848451400, ss5936567972, ss5951544465 NC_000017.10:44248498:G:C NC_000017.11:46171132:G:C (self)
RCV001514335.4, RCV001528289.4, RCV001598654.3, 94511929, 508000751, 1492047, 112628785, 252402183, 8778547255, ss2217035922, ss3028358210, ss3650660799, ss3700517862, ss3819964838, ss5036856521, ss5236943900, ss5237669249, ss5303223893, ss5496267413, ss5606985994, ss5778791681, ss5816562251, ss5851816601 NC_000017.11:46171132:G:C NC_000017.11:46171132:G:C (self)
ss20040830, ss21425392 NT_010783.14:2902554:G:C NC_000017.11:46171132:G:C (self)
ss3196498, ss6613951, ss24109002, ss44011651, ss48425062, ss65737906, ss96596662, ss136561544, ss158054483, ss159735654, ss410920822 NT_010783.15:9522650:G:C NC_000017.11:46171132:G:C (self)
42679425, ss3935502031 NC_000017.10:44248498:G:T NC_000017.11:46171132:G:T (self)
8778547255 NC_000017.11:46171132:G:T NC_000017.11:46171132:G:T (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

No publications for rs2240758

Help

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post761+d5e8e07