RELEASE: NCBI dbSNP Build 135 for human
                         

dbSNP Build 135 for human (txid 9606)
===================================
This release is based on NCBI human genome build 37.3 that included assembly
changes described here (http://1.usa.gov/fIk86S) and include new submissions
from 1000 Genomes Project Phase I release (http://1.usa.gov/rhf62b).

dbSNP Handle    ss_cnt		rs_cnt
------------	-------		-------
1000GENOMES* 	57911353	39484957

*Includes Pilot 1,2,3 and Phase I June 2011 release (http://bit.ly/q8a5Wy) 


Build Summary
-------------

	organism: Homo sapiens
	tax_id: 9606	
	total_ss: 178,140,838
	total_rs: 52,345,594
	new_ss(since b134 release on Aug.8, 2011): 167,018
	new_rs(since b134 release on Aug.8, 2011): 12,632,872


Component availability dates:

      Component                 Date available
      dbSNP web query           October 13, 2011
      BLAST databases           October 24, 2011 (estimated)
      FTP data                  October 24, 2011 (estimated)
      Entrez Search           	October 24, 2011 (estimated)
      
 
* All formats and conventions are described in
ftp.ncbi.nih.gov/snp/00readme.txt. Please note that the README document is
updated periodically. 
* The complete data for build 135 will be available in multiple formats by
organisms at
ftp://ftp.ncbi.nih.gov/snp/organisms/  
* The complete build summary for build 135 is available
at:www.ncbi.nlm.nih.gov/SNP/snp_summary.cgi

Important updates and new features: 

1)  About dbSNP: 
Content in dbSNP is not limited to single nucleotide polymorphisms (SNPs), but
stores information about multiple small-scale variations that include
insertions/deletions, microsatellites, and non-polymorphic variants. dbSNP also
stores common and rare variations along with their genotypes and allele
frequencies. Most importantly, dbSNP includes clinically significant human
variations as well as benign polymorphisms.

dbSNP also aggregates user assertions for these variations, including its
clinical assertion, minor allele frequencies, the likelihood that the variation
is a false positive, and whether the allele origin is germline or somatic. 
For detail descriptions, please visit the following site:
(http://www.ncbi.nlm.nih.gov/projects/SNP/docs/rs_attributes.html). 


2) New Feature: Filtered VCF files
dbSNP is preparing specially filtered VCF data files to provide reasonable
subsets of dbSNP selected to act as surrogates for 'polymorphic' or 'rare'
variants. These subsets are defined using minor allele frequencies (MAF) and
sources (http://1.usa.gov/qWA9oE), and the individual files include the following: 1) MAF
> 0.01 based on 1000 Genomes populations, 2) MAF > 0.01 for any population
submitted to dbSNP, 3) MAF > 0.01 for all populations submitted to dbSNP. A
separate announcement will be sent when these files are available on the FTP
site (ftp://ftp.ncbi.nih.gov/snp/organisms/human_9606/VCF/v4.0/) for dbSNP human
Build 135 in a few weeks.   

3) Known Issues:

Due to the volume of data, 1000Genomes genotype is not loaded directly to dbSNP
so it's not reported in "new ss/rs with genotype" count.  However, the global
minor allele frequency (MAF) will be calculated and included with the build
release (http://1.usa.gov/pVHRaA).   The genotype data can be download directly
from 1000Genomes FTP site (http://www.1000genomes.org/data).


dbSNP Production Team
October 13, 2011
National Center for Biotechnology Information (NCBI)
National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
RSS: http://www.ncbi.nlm.nih.gov/feed/rss.cgi?ChanKey=dbsnpnews
Help Desk: snp-admin@ncbi.nlm.nih.gov