RELEASE: NCBI dbSNP Build 134 for human
                         

dbSNP Build 134 for human (txid 9606)
===================================
This release is based on Genome Reference Consortium (GRC) assembly GRCh37.p2, 
which is a patch release of GRCh37 that has minor changes described in a README 
document(http://bit.ly/mQjIii).  dbSNP build 134 includes new submissions from 
the 1000 Genomes Project interim phase I release(dbSNP Handle: 1000Genomes)and 
the NHLBI Exome Sequencing Project (dbSNP handle: NHLBI-ESP).


handle          ss_cnt		rs_cnt
-------		-------		-------
1000GENOMES* 	15893853	14877247
NHLBI-ESP         526799	526799

 
Build 134 added 18 new organisms [6,038,585 submissions(ss#)]to dbSNP.  
Overall, with these new organisms included, build 134 added 108,182,122 new 
ss# to dbSNP representing a total of 86 organisms.  

 
 Component availability dates:

      Component                 Date available
      dbSNP web query           August 15, 2011
      BLAST databases           August 22, 2011 (estimated)
      FTP data                  August 22, 2011 (estimated)
      Entrez indexing           August 22, 2011 (estimated)
      
 
* All formats and conventions are described in ftp.ncbi.nih.gov/snp/00readme.txt. 
Please note that the README document is updated only periodically. 

* The complete data for build 134 will be available in multiple formats sorted by
organism at ftp://ftp.ncbi.nih.gov/snp/organisms/  

* The complete build summary for 134 is available 
at: www.ncbi.nlm.nih.gov/SNP/snp_summary.cgi

Recent updates and new features: 

1) dbSNP logo change (http://www.ncbi.nlm.nih.gov/projects/SNP/)

As there has been confusion about the types of variations dbSNP actually contains, 
the dbSNP logo text was changed from "Single Nucleotide Polymorphism" to 
"Short Genetic Variations".  We hope that this change will reflect the wide 
range of dbSNP's variation content, and thereby prevent any future misunderstandings.

In spite of its name, dbSNP is not limited to single nucleotide polymorphisms
(SNPs), but stores information about multiple small-scale variations that
include insertions/deletions, microsatellites, and non-polymorphic variants.
dbSNP also stores common and rare variations along with their genotypes and
allele frequencies. 

Most importantly, dbSNP includes clinically significant variations, and should 
NOT be assumed to hold only benign polymorphisms.


2) New refSNP Attributes 

dbSNP has added new attributes that allow searching and filtering of human variation 
by clinical significance, allele origin, minor allele frequency, and suspected false
SNPs.  See http://www.ncbi.nlm.nih.gov/projects/SNP/docs/rs_attributes.html
for more information and examples of the changes these filters have on RefSNP pages.


3) New dbSNP News Web Feed

A new RSS feed for brief announcements that highlight recent enhancements and changes 
to the dbSNP database is now available at: 
http://www.ncbi.nlm.nih.gov/feed/rss.cgi?ChanKey=dbsnpnews


4) Gene ID added to VCF (Variant Call Format) for human

Data in the Variant Call Format is available on the dbSNP ftp site:
ftp://ftp.ncbi.nih.gov/snp/organisms/human_9606/VCF

For more information see:
ftp://ftp.ncbi.nih.gov/snp/organisms/human_9606/VCF/v4.0/000-README.txt
and 
http://www.1000genomes.org/node/101 




dbSNP Production Team
August 15, 2011
National Center for Biotechnology Information (NCBI)
National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.