| Nef | Co-localizes with | Ras-related protein Rab-11A  |
| Induces release of | Fc fragment of IgE, low affinity II, receptor for (CD23A) |
| | intercellular adhesion molecule 1 precursor |
| Inhibits | hemopoietic cell kinase isoform p61HCK |
| | interleukin 2 precursor |
| | mitogen-activated protein kinase 1 |
| Interacts with | adaptor-related protein complex 1, mu 1 subunit |
| | chemokine (C-X-C motif) receptor 4 isoform b |
| | dedicator of cytokinesis 2 |
| | DnaJ (Hsp40) homolog, subfamily B, member 1 |
| | engulfment and cell motility 1 isoform 1 |
| | inositol 1,4,5-triphosphate receptor, type 1 |
| | lymphocyte-specific protein tyrosine kinase precursor |
| | ras-related C3 botulinum toxin substrate 1 isoform Rac1 |
| | ras-related C3 botulinum toxin substrate 2 |
| | T-cell receptor zeta chain isoform 1 precursor |
| Modulates | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
| Requires | adaptor-related protein complex 2, mu 1 subunit isoform a |
| Upregulates | DnaJ (Hsp40) homolog, subfamily B, member 1 |
| | T-cell receptor zeta chain isoform 1 precursor |
| activates | adenylate cyclase 2 |
| | adenylate cyclase 3 |
| | adenylate cyclase 4 |
| | adenylate cyclase 5 |
| | adenylate cyclase 6 isoform a |
| | adenylate cyclase 7 |
| | adenylate cyclase 8 |
| | adenylate cyclase 9 |
| | ADP-ribosylation factor 6 |
| | brain adenylate cyclase 1 |
| | caspase 3 preproprotein |
| | hemopoietic cell kinase isoform p61HCK |
| | interferon regulatory factor 3 |
| | jun oncogene |
| | matrix metalloproteinase 9 preproprotein |
| | mitogen-activated protein kinase 1 |
| | mitogen-activated protein kinase 14 isoform 1 |
| | mitogen-activated protein kinase 3 isoform 1 |
| | mitogen-activated protein kinase 8 isoform JNK1 alpha2 |
| | nuclear factor kappa-B, subunit 1 |
| | nuclear factor of activated T-cells, cytosolic component 1 isoform A |
| | p21-activated kinase 1 |
| | p21-activated kinase 2 |
| | ras-related C3 botulinum toxin substrate 1 isoform Rac1 |
| | signal transducer and activator of transcription 1 isoform alpha |
| | signal transducer and activator of transcription 3 isoform 1 |
| | v-fos FBJ murine osteosarcoma viral oncogene homolog |
| | v-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1 |
| | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog |
| associates with | actin, gamma 1 propeptide |
| | beta actin |
| | p21-activated kinase 1 |
| | p21-activated kinase 2 |
| binds | adaptor-related protein complex 1 beta 1 subunit isoform a |
| | adaptor-related protein complex 1 sigma 2 subunit |
| | adaptor-related protein complex 1, gamma 1 subunit isoform b |
| | adaptor-related protein complex 1, gamma 2 subunit |
| | adaptor-related protein complex 1, mu 1 subunit |
| | adaptor-related protein complex 1, sigma 1 subunit isoform 1 |
| | adaptor-related protein complex 1, sigma 3 subunit |
| | adaptor-related protein complex 2, beta 1 subunit isoform b |
| | adaptor-related protein complex 3, delta 1 subunit isoform 2 |
| | ADP-ribosylation factor 1 |
| | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H isoform 1 |
| | calmodulin 1 |
| | CD4 antigen precursor |
| | CD80 antigen precursor |
| | CD86 antigen isoform 1 |
| | coatomer protein complex, subunit beta |
| | embryonic ectoderm development isoform a |
| | GATA binding protein 1 |
| | GATA binding protein 3 isoform 2 |
| | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 |
| | guanine nucleotide binding protein, alpha activating polypeptide O |
| | hemopoietic cell kinase isoform p61HCK |
| | lymphocyte-specific protein tyrosine kinase precursor |
| | major histocompatibility complex, class I, A precursor |
| | major histocompatibility complex, class I, B |
| | major histocompatibility complex, class I, C precursor |
| | major histocompatibility complex, class I, E precursor |
| | major histocompatibility complex, class I, F precursor |
| | major histocompatibility complex, class I, G precursor |
| | mitogen-activated protein kinase 1 |
| | mitogen-activated protein kinase kinase kinase 5 |
| | Nef-associated factor 1 |
| | p21-activated kinase 2 |
| | peptidylprolyl isomerase A |
| | peroxisomal acyl-CoA thioesterase 1 isoform a |
| | phosphofurin acidic cluster sorting protein 1 |
| | phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 1 |
| | programmed cell death 6 interacting protein |
| | proteasome beta 4 subunit |
| | protein-tyrosine kinase fyn isoform a |
| | proto-oncogene tyrosine-protein kinase SRC |
| | tumor protein p53 |
| | v-raf-1 murine leukemia viral oncogene homolog 1 |
| | vav 1 oncogene |
| co-localizes with | adaptor-related protein complex 2, beta 1 subunit isoform b |
| | adaptor-related protein complex 3, delta 1 subunit isoform 2 |
| | CD28 antigen |
| | CD8b antigen isoform 1 precursor |
| | coatomer protein complex, subunit beta |
| | glial fibrillary acidic protein |
| | major histocompatibility complex, class I, A precursor |
| | major histocompatibility complex, class I, B |
| | p21-activated kinase 2 |
| degrades | CD4 antigen precursor |
| | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| downregulates | ATP-binding cassette, sub-family A member 1 |
| | B-cell lymphoma protein 2 alpha isoform |
| | BCL2-like 1 isoform 1 |
| | CD1A antigen precursor |
| | CD1D antigen precursor |
| | CD28 antigen |
| | CD3D antigen, delta polypeptide isoform A precursor |
| | CD3E antigen, epsilon polypeptide (TiT3 complex) |
| | CD3G gamma precursor |
| | CD4 antigen precursor |
| | CD69 antigen (p60, early T-cell activation antigen) |
| | CD8 antigen alpha polypeptide isoform 1 precursor |
| | CD80 antigen precursor |
| | CD86 antigen isoform 1 |
| | CD8b antigen isoform 1 precursor |
| | chemokine (C-C motif) receptor 5 |
| | chemokine (C-X-C motif) receptor 4 isoform b |
| | cyclin E1 isoform 1 |
| | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
| | Fc fragment of IgG, low affinity IIa, receptor for (CD32) |
| | Fc fragment of IgG, low affinity IIb, receptor for (CD32) isoform 1 |
| | hemochromatosis protein isoform 1 precursor |
| | interferon, gamma |
| | interleukin 2 precursor |
| | interleukin 2 receptor, alpha chain precursor |
| | jun oncogene |
| | major histocompatibility complex, class I, A precursor |
| | major histocompatibility complex, class I, B |
| | major histocompatibility complex, class I, C precursor |
| | major histocompatibility complex, class I, E precursor |
| | major histocompatibility complex, class I, F precursor |
| | major histocompatibility complex, class I, G precursor |
| | major histocompatibility complex, class II, DR alpha precursor |
| | mannose receptor C type 1 precursor |
| | nuclear factor kappa-B, subunit 1 |
| | peroxisome proliferative activated receptor gamma isoform 1 |
| | phosphoinositide-3-kinase, catalytic, alpha polypeptide |
| | proteasome beta 4 subunit |
| | protein kinase C, beta isoform 2 |
| | protein kinase C, epsilon |
| | synaptopodin |
| | transferrin receptor |
| | v-fos FBJ murine osteosarcoma viral oncogene homolog |
| | Wilms tumor 1 isoform A |
| inactivates | caspase 3 preproprotein |
| | caspase 8 isoform A precursor |
| | lymphocyte-specific protein tyrosine kinase precursor |
| induces cleavage of | poly (ADP-ribose) polymerase family, member 1 |
| induces complex with | Cas-Br-M (murine) ecotropic retroviral transforming sequence |
| | Rho guanine nucleotide exchange factor 7 isoform a |
| induces phosphorylation of | BCL2-antagonist of cell death protein |
| | Cas-Br-M (murine) ecotropic retroviral transforming sequence |
| | conserved helix-loop-helix ubiquitous kinase |
| | ELK1 protein |
| | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| | neurofibromin 2 isoform 1 |
| | Rac/Cdc42 guanine nucleotide exchange factor 6 |
| induces rearrangement of | actin, gamma 1 propeptide |
| | beta actin |
| inhibits | apolipoprotein A-I preproprotein |
| | CD40 ligand |
| | cell division cycle 42 isoform 1 |
| | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) isoform beta |
| | chemokine (C-X-C motif) receptor 4 isoform b |
| | colony stimulating factor 1 receptor precursor |
| | endothelin 1 |
| | interleukin 10 precursor |
| | interleukin 2 precursor |
| | interleukin 4 isoform 1 precursor |
| | major histocompatibility complex, class I, A precursor |
| | major histocompatibility complex, class II, DR alpha precursor |
| | mitogen-activated protein kinase 1 |
| | mitogen-activated protein kinase kinase kinase 5 |
| | NADPH oxidase 1 isoform long |
| | nuclear factor kappa-B, subunit 1 |
| | nuclear factor of activated T-cells, cytosolic component 1 isoform A |
| | tumor necrosis factor alpha |
| | tumor necrosis factor receptor superfamily, member 6 isoform 1 precursor |
| | Wiskott-Aldrich syndrome gene-like protein |
| interacts with | adaptor-related protein complex 1 beta 1 subunit isoform a |
| | adaptor-related protein complex 1 sigma 2 subunit |
| | adaptor-related protein complex 1, gamma 2 subunit |
| | adaptor-related protein complex 1, mu 1 subunit |
| | adaptor-related protein complex 1, sigma 1 subunit isoform 1 |
| | adaptor-related protein complex 1, sigma 3 subunit |
| | adaptor-related protein complex 3, mu 1 subunit |
| | beta actin |
| | calmodulin 1 |
| | calmodulin 2 |
| | calmodulin 3 |
| | CD4 antigen precursor |
| | CD80 antigen precursor |
| | cell division cycle 42 isoform 1 |
| | chemokine (C-X-C motif) receptor 3 |
| | chemokine (C-X-C motif) receptor 4 isoform b |
| | clathrin heavy chain 1 |
| | cyclin-dependent kinase 9 |
| | DnaJ (Hsp40) homolog, subfamily B, member 1 |
| | hemopoietic cell kinase isoform p61HCK |
| | integrin alpha L precursor |
| | integrin alpha M precursor |
| | intercellular adhesion molecule 1 precursor |
| | interleukin 2 precursor |
| | lymphocyte-specific protein tyrosine kinase precursor |
| | major histocompatibility complex, class II, DR beta 1 precursor |
| | N-myristoyltransferase 1 |
| | p21-activated kinase 2 |
| | phosphoinositide-3-kinase, catalytic, alpha polypeptide |
| | protein kinase C, theta |
| | ras-related C3 botulinum toxin substrate 1 isoform Rac1 |
| | T-cell receptor zeta chain isoform 1 precursor |
| | tumor protein p53 |
| | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog |
| modulates | CD4 antigen precursor |
| | major histocompatibility complex, class I, A precursor |
| | major histocompatibility complex, class I, B |
| | sphingomyelin phosphodiesterase 1, acid lysosomal isoform 1 precursor |
| | transferrin receptor |
| myristoylated by | N-myristoyltransferase 1 |
| phosphorylated by | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 |
| | protein kinase C, alpha |
| polarizes | vinculin isoform VCL |
| regulated by | ADP-ribosylation factor 6 |
| | mitogen-activated protein kinase 1 |
| relocalizes | embryonic ectoderm development isoform a |
| | ubiquitin-conjugating enzyme E2L 3 isoform 1 |
| requires | adaptor-related protein complex 2, mu 1 subunit isoform a |
| | calmodulin 1 |
| | calmodulin 2 |
| | calmodulin 3 |
| | caspase 3 preproprotein |
| | hemopoietic cell kinase isoform p61HCK |
| | lymphocyte-specific protein tyrosine kinase precursor |
| stabilizes | adaptor-related protein complex 1 beta 1 subunit isoform a |
| | adaptor-related protein complex 1 sigma 2 subunit |
| | adaptor-related protein complex 1, gamma 1 subunit isoform b |
| | adaptor-related protein complex 1, gamma 2 subunit |
| | adaptor-related protein complex 1, mu 1 subunit |
| | adaptor-related protein complex 1, sigma 1 subunit isoform 1 |
| | adaptor-related protein complex 1, sigma 3 subunit |
| | thioredoxin |
| synergizes with | v-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1 |
| upregulates | activating transcription factor 3 isoform 1 |
| | antigen identified by monoclonal antibody Ki-67 |
| | BCL2-like 1 isoform 1 |
| | caspase 9 isoform alpha preproprotein |
| | CD14 antigen precursor |
| | CD209 antigen |
| | CD22 antigen |
| | CD28 antigen |
| | CD58 antigen, (lymphocyte function-associated antigen 3) |
| | CD74 antigen isoform b |
| | cell division cycle 42 isoform 1 |
| | chemokine (C-C motif) ligand 3 |
| | chemokine C-C motif ligand 4 isoform 1 precursor |
| | complement component 3 precursor |
| | complement component 5 receptor 1 (C5a ligand) |
| | cyclin D1 |
| | cyclin-dependent kinase 9 |
| | cytochrome P450, family 51 |
| | cytotoxic T-lymphocyte-associated protein 4 isoform a precursor |
| | dermatopontin precursor |
| | elongin A |
| | fas ligand |
| | fibronectin 1 isoform 1 preproprotein |
| | glial fibrillary acidic protein |
| | granzyme A precursor |
| | growth factor receptor-bound protein 2 isoform 1 |
| | helicase-like transcription factor |
| | HIV TAT specific factor 1 |
| | interferon regulatory factor 1 |
| | interferon regulatory factor 2 |
| | interferon, beta 1, fibroblast |
| | interferon, gamma |
| | interleukin 1, beta proprotein |
| | interleukin 10 precursor |
| | interleukin 12A precursor |
| | interleukin 15 preproprotein |
| | interleukin 2 precursor |
| | interleukin 6 (interferon, beta 2) |
| | interleukin 8 precursor |
| | low density lipoprotein receptor precursor |
| | lymphocyte-specific protein tyrosine kinase precursor |
| | mitogen-activated protein kinase 1 |
| | mitogen-activated protein kinase kinase 1 |
| | mitogen-activated protein kinase kinase 2 |
| | nuclear factor of activated T-cells, cytosolic component 1 isoform A |
| | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| | phosphoinositide-3-kinase, catalytic, alpha polypeptide |
| | PTK2B protein tyrosine kinase 2 beta isoform a |
| | retinoblastoma 1 |
| | signal transducer and activator of transcription 3 isoform 1 |
| | small inducible cytokine A2 precursor |
| | small inducible cytokine A5 precursor |
| | small inducible cytokine B10 precursor |
| | small nuclear ribonucleoprotein polypeptide A |
| | sterol regulatory element-binding transcription factor 2 |
| | suppressor of cytokine signaling 1 |
| | transcription factor 8 (represses interleukin 2 expression) |
| | tumor necrosis factor alpha |
| | tumor necrosis factor ligand superfamily, member 14 isoform 1 precursor |
| | tumor necrosis factor receptor superfamily, member 6 isoform 1 precursor |
| | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog precursor |
