|NCBI Home RefSeq HIV-1, Human Protein Interaction Database|
Interaction data results:
Last updated: December 2012
The HIV-1, human protein interaction data presented here are based on literature reports. This dataset is available in report pages per HIV-1 protein and is also integrated into Entrez Gene report pages for HIV-1 and human proteins. The complete dataset is also available for FTP. [more...]
Note: To identify new submissions, please use the Entrez "Limits" page. For example, select "30 days" from the menu entitled "Published in the last:". A range of date and other options are available.
Documenting the interaction of human immunodeficiency virus type 1 (HIV-1) proteins with those of the host cell is crucial to understanding the process of HIV-1 replication and pathogenesis, and provides an essential foundation for the development of safe and effective therapeutic and prevention strategies to combat AIDS. Although numerous interactions have been reported in the scientific literature there is currently no publicly available source for efficiently accessing this information. Therefore, the Division of Acquired Immunodeficiency Syndrome (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID) has initiated a project, in collaboration with Southern Research Institute and the National Center for Biotechnology Information (NCBI), designed to compile a comprehensive database of the described interactions between HIV-1 and cellular proteins.
The goal of this project is to provide scientists in the field of HIV/AIDS research a concise, yet detailed, summary of all known interactions of HIV-1 proteins with host cell proteins, other HIV-1 proteins, or proteins from disease organisms associated with HIV/AIDS. To this end, the database has been designed to track the following information for each protein-protein interaction identified in the literature:
Please use these articles to cite use of the HIV-1, human protein interaction dataset and web resources:
Human immunodeficiency virus type 1, human protein interaction database at NCBI
Cataloguing the HIV-1 Human Protein Interaction Network.
HIV-host interactions: a map of viral perturbation of the host system.
The initial review of the scientific literature and development of the database was performed by Mr. Roger Ptak, Dr. William Fu, and Dr. Brigitte Beer (Southern Research Institute, Frederick, Maryland). The work was supported by NIH contracts N01-AI-05415, Specialized In Vitro Virological Evaluations Of Strategies To Combat HIV/AIDS, and N01-AI-70042, In Vitro Testing Resources for AIDS Therapeutic Development Part B: Specialized In Vitro Virological Assays for HIV Therapeutics and Topical Microbicides, under direction of Dr. Roger Miller, Project Officer, DAIDS, NIAID. DAIDS gratefully acknowledges the efforts of Drs. Kim Pruitt, Donna Maglott, and Ken Katz (NCBI, NLM) for linking the database to NCBI programs and overseeing the updating of the database .
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Protein Interaction DBs