Malaria Genetics & Genomics African tree rats are closely related to field mice, and the laboratory rat and mouse. Their natural habitat is the gallery forests found lining streams and rivers, where they build nests of leaves at heights of 2 to 3 m above ground. Colonies of thicket rats have been introduced into the laboratory for use in parasitological studies, with limited sucess due to their poor breeding performance under laboratory conditions.
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   Plasmodium vinckei

P.vinckei was first isolated in 1952 although it was not recognized as an independent species until 1975. It is the most widely distributed of the species of murine Plasmodium, being found in Katanga, the Central African Republic, the Congo Republic, Nigeria, and Cameroon. Four subspecies are recognized, P.vinckei vinckei, P.vinckei petteri, P.vinckei lentum and P.vinckei brucechwatti. The parasite is readily grown in mice and laboratory-reared thicket rats, where it shows a preference for mature red blood cells . Infections are synchronous with a periodicity of 24 hours. The parasite may be transmitted in the laboratory by Anopheles stephensi mosquitoes over a wide temperature range.

o The P.vinckei genome

P.vinckei has 14 chromosomes visualized by pulsed-field gel electrophoresis. Genome size is estimated to be close to that of P. falciparum at 25-30 Mb.

Last updated: Mar 15, 2000

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