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Terms
and Definitions Commonly Used in Malaria Genetics and Genomics |
| Isolate |
A sample of parasites taken from an infected person
or animal on a unique occasion; an isolate is uncloned, and thus may
contain more than one genetically distinct parasite clone. |
| Line |
Parasites of a single species derived from a single
isolate, not necessarily cloned that have some common phenotype, e.g.,
drug resistance. |
| Clone |
The progeny of a single parasite, normally obtained
by manipulation or serial dilution of uncloned parasites and then
maintained in the laboratory. All of the members of a clone have been
classically defined as genetically identical, but this is not necessarily
the case because members of the clone may undergo mutations, chromosomal
rearrangements, etc. that may survive in the culture conditions |
| Country of origin |
Country of origin where the infection originated,
not necessarily where it was isolated. "Country of origin"
is now a feature qualifier in nucleotide records in GenBank/EMBL/DDBJ
and will be useful in population and epidemiological studies in the
future. |
Two references for malaria genetic terminology are:
Beale GH, Carter R, Walliker D. Genetics in "Rodent Malaria" Killick-Kendrick
R, Peters W. editors. New York: Academic Press. 1978. p. 213-245.
Kemp DJ, Cowman AF, Walliker D. Genetic diversity in Plasmodium falciparum.
Adv Parasitol 1990; 29:75-149. PubMed
Revised: March 15, 2000
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