PMC

Segments of exon 3 HRAS sequencing electropherogram, forward. a Arrow indicates c.182A>G substitution, resulting in p.Q61R missense heterozygous mutation. b Arrow indicates c.181C>A substitution, resulting in p.Q61 K missense heterozygous mutation

Morphologic subtypes of EMCa with HRAS mutations. a This classic EMCa from the parotid (100×) harbored p.Q61R mutation. b This oncocytic EMCa (100×) of parotid on the other hand showed a p.Q61 K mutation. c This submandibular tumor with a p.Q61 K mutation is an aggressive tumor showing myoepithelial overgrowth and necrosis (100×). Arrow indicates the rare compressed ductal component