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1.
FIGURE 8

FIGURE 8. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Enlarged rat spleen with myeloid and erythroid hyperplasia.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
2.
FIGURE 14

FIGURE 14. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

C3H/lpr mouse with lymphoproliferative disease. A monomorphic population of medium-sized T-cells is seen.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
3.
FIGURE 1

FIGURE 1. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Thymus of an eighteen-month-old B6,129 mouse showing nodular medullary hyperplasia.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
4.
FIGURE 13

FIGURE 13. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Greatly enlarged lymph nodes of a six-month-old C3H/lpr mouse with lymphoproliferative disease.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
5.
FIGURE 5

FIGURE 5. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Greatly enlarged spleen of a mouse infected with Plasmodium berghei ten days previously.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
6.
FIGURE 16

FIGURE 16. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Normal splenic white pulp with many mature lymphocytes (centrocytes) in the eighteen-month-old C57BL/6NCr mouse from .

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
7.
FIGURE 9

FIGURE 9. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Enlarged rat spleen with myeloid and erythroid hyperplasia also has many plasma cells expressing IgG. Immunohistochemistry for rat IgG.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
8.
FIGURE 2

FIGURE 2. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Thymus of another eighteen-month-old B6,129 mouse with medullary hyperplasia and CD3 expression in T-cells. Note that there is loss of CD3+ lymphocytes in the medullary hyperplasia.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
9.
FIGURE 12

FIGURE 12. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Spleen of a mouse with later stage murine acquired immunodeficiency syndrome showing many centroblasts with mitotic figures.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
10.
FIGURE 3

FIGURE 3. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Thymus of an eighteen-month-old B6,129 mouse with medullary hyperplasia showing CD45R expression. Note the increase in CD45R+ B cells in several areas.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
11.
FIGURE 15

FIGURE 15. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Spleen of a twenty-four-month-old C57BL/6NCr mouse with one enlarged white pulp area (upper left), which represents an early follicular lymphoma.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
12.
FIGURE 7

FIGURE 7. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Spleen in a malaria-infected mouse with numerous plasma cells. Immunohistochemistry for human κ light chains expressed mostly in the plasma cells.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
13.
FIGURE 10

FIGURE 10. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Enlarged spleen of a mouse with early stage murine acquired immunodeficiency syndrome showing hyperplasia of the white pulp.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
14.
FIGURE 17

FIGURE 17. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

White pulp of the mouse in showing early follicular lymphoma containing a mixed population of centroblasts and centrocytes, including cells with cleaved nuceli.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
15.
FIGURE 6

FIGURE 6. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Spleen of mouse infected with P. berghei ten days earlier. The red pulp is expanded with prominent erythroid hyperplasia, and the white pulp has marked germinal center and plasma cell hyperplasia.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
16.
FIGURE 11

FIGURE 11. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

High magnification of previous figure of a mouse with murine acquired immunodeficiency syndrome showing a heterogeneous population of plasmacytoid cells, immature and mature plasma cells.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
17.
FIGURE 18

FIGURE 18. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

Spleen of a B6C3F1 mouse with early follicular lymphoma in one large white pulp area. There is a loss of dense cellular CD45R expression in the early lymphoma.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.
18.
FIGURE 4

FIGURE 4. From: Differentiation of Rodent Immune and Hematopoietic System Reactive Lesions from Neoplasias.

A much enlarged mandibular lymph node of a mouse with ulcerative skin lesions. There is loss of normal nodal architecture. Most of the node contains mature plasma cells.

Jerrold M. Ward, et al. Toxicol Pathol. ;40(3):425-434.

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