(A) ADP-stimulated (state 3) respiration on pyruvate, (B) oligomycin-insensitive (state 4) respiration on pyruvate, (C) maximally uncoupled (state UnC) respiration on pyruvate, (D) state 3 respiration on palmitoylCoA + carnitine, (E) state 4 respiration on palmitoyl-CoA + carnitine and (F) State UnC respiration on palmitoyl-CoA + carnitine. Black and white bars represent LFD mice and HFD mice, respectively. Values are means ± SE (n = 7–8). D, significant diet effect with p<0.01; T, significant time effect with p<0.05 in state 3 and state 4 and with p<0.01 in state UnC; D*T, significant diet * time effect with p<0.05; HFD, high fat diet; LFD, low fat diet; TA, tibialis anterior; UnC, uncoupled.