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1.
Figure 3

Figure 3. Effects of prenatal stress on the levels of Bcl-2 and Bax.. From: Prenatal Stress Induces Long-Term Effects in Cell Turnover in the Hippocampus-Hypothalamus-Pituitary Axis in Adult Male Rats.

Immunoblots probed with antibodies towards Bcl-2 (A) and Bax (B) in the hippocampus, hypothalamus and pituitary of control rats and prenatally stressed rats (PS). Statistical significance by Student’s t test: * P<0.05; ** P<0.01 and *** P<0.001; n = 3-4/group.

Eva Baquedano, et al. PLoS One. 2011;6(11):e27549.

CitationFull text

2.
Figure 5

Figure 5. Diagram representing the mechanism proposed for prenatal stress inhibition of cell death. From: Prenatal Stress Induces Long-Term Effects in Cell Turnover in the Hippocampus-Hypothalamus-Pituitary Axis in Adult Male Rats.

. Prenatal stress would induce an increase in local IGF-I levels that would induce an increase in calpastatin levels via CREB that would in turn inhibit calpain -2. Furthermore, IGF-I would stimulate Bcl-2 leading to decreased levels of p-p53 and finally to a less activation of the extrinsic apoptosis pathway.

Eva Baquedano, et al. PLoS One. 2011;6(11):e27549.

CitationFull text

3.
Figure 4

Figure 4. Effects of prenatal stress on the levels of p-53 and CREB.. From: Prenatal Stress Induces Long-Term Effects in Cell Turnover in the Hippocampus-Hypothalamus-Pituitary Axis in Adult Male Rats.

Immunoblots probed with antibodies towards phosphorylated (p)-p53 (A) and p-CREB (B) in the hippocampus, hypothalamus and pituitary of control rats and prenatally stressed rats (PS). The average of three independent assays is shown Statistical significance by Student’s t test: * P<0.05 and ** P<0.01; n = 3–4/group.

Eva Baquedano, et al. PLoS One. 2011;6(11):e27549.

CitationFull text

4.
Figure 2

Figure 2. Prenatal stress increases calpastatin and IGF-I mRNA levels.. From: Prenatal Stress Induces Long-Term Effects in Cell Turnover in the Hippocampus-Hypothalamus-Pituitary Axis in Adult Male Rats.

(A) Immunoblots probed with antibodies towards calpastatin in the hippocampus, hypothalamus and pituitary of control rats and prenatally stressed rats (PS); (B) Relative mRNA levels of IGF-I in the hippocampus, hypothalamus and pituitary of control and PS rats. The average of three independent assays is shown. Statistical significance by Student’s t test: * P<0.05 and ** P<0.01; n = 3–4/group.

Eva Baquedano, et al. PLoS One. 2011;6(11):e27549.

CitationFull text

5.
Figure 1

Figure 1. Prenatal stress reduces the fragmentation of caspase-8 and calpain-2.. From: Prenatal Stress Induces Long-Term Effects in Cell Turnover in the Hippocampus-Hypothalamus-Pituitary Axis in Adult Male Rats.

Immunoblots probed with antibodies towards caspase -8 (A) and calpain -2 (B) in the hippocampus, hypothalamus and pituitary of control rats and prenatally stressed rats (PS). The average of three independent assays is shown. Statistical significance by Student’s t test: * P<0.05 and ** P<0.01; n = 3–4/group.

Eva Baquedano, et al. PLoS One. 2011;6(11):e27549.

CitationFull text

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