Changes in hepatic gene expression of BA metabolism in STAT5-deficient mice. STAT5-liver specific knockout mice (STAT5−/ −) exhibited changes in gene expression of BA metabolism including synthesis,,,, uptake,,, and detoxification.,, Sult2a1 gene was induced in GH-releasing hormone receptor-deficient little (lit/lit) mouse. Ntcp, Na+/taurocholate cotransporter; Oatp1, organic anion transporter 1; BA, bile acid; Gstπ, glutathione S-transferase pi class; Chol, cholesterol; E2, estradiol; OA-, organic anions; BA-OH, hydroxylated BA; BA-SO3, sulfated BA; GSH, glutathione. Arrows indicate changes in gene expression (up, down). NC, no change.