PMC

Schematic depiction of laceration wound.

A complex wound involving injury to muscle, fascia, periosteum and bone.

Surgical site infections (SSIs) are classified as superficial incisional SSI, deep incisional SSI and organ/space SSIs.

(A) Wound morphology at day 4 post-infection of a representative mouse wound. (B) A Gram-stained section of a mouse skin abrasion specimen showing the biofilms formed by Gram-positive MRSA near the skin surface. Dark blue area: biofilms of MRSA. The mouse skin abrasion specimen was harvested at day 3 post-infection.

Full-thickness burn was created by applying two pre-heated brass blocks (92–95°C) to the opposing sides of an elevated skin fold on the back of a shaved mouse. Square: burned area. Bacteria were applied to surface of burn as a suspension in PBS.