PMC

Characteristics of RDD sites. (A) Frequency of the 12 categories of RNA-DNA differences identified in B cells of 27 normal individuals. (B) Number of RNA editing or RDD events in 27 normal individuals. (C) Bimodal distribution of the levels of 28,766 RNA editing or RDD events.

Identification of peptides coded by both RNA and DNA sequences. (A) The RNA form of a RDD leads to loss of a stop codon in RPL28 and extension of 55 amino acids. Peptides detected by mass spectrometry are shown in red. Extended protein sequence due to RDD is underlined. (B and C) Tandem mass spectrometry (MS-MS) data confirm the detection of peptides encoded by the RDD-containing RPL28 mRNA. The representative spectra of one peptide (SLIGTASEPR) from ovarian cancer cells (B) and cultured B cells (C) are shown.